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I've just been in touch with Arnika Apothecary in Germany. They are an often quoted source of methylcobalamin ampules. Before ordering from them, I inquired as to their light exposure precautions during production. This is their response:
"We manufacture the methylcobalamin ampoules in our clean rooms. These are of course protected from direct sunlight. We do not use any other special light protection during production. After production, the ampoules are packed in paper boxes and are therefore protected from sunlight. They should only be removed immediately before the injection."
I have a paper called Methylcobalamin and Light from Compounder's International Analytical Library (located in Colorado). In the paper, we find this paragraph:
"When formulating methylcobalamin, many are aware of its sensitivity to light but may not know just how sensitive it is. In our lab we carried out an experiment to see just how sensitive a typical formulation might be to typical interior lab lighting. The formulation we selected as our test sample was one containing methylcobalamin 1000 mcg/mL in normal saline plus benzyl alcohol 2%. We assayed the sample to check its potency and found it to be 985mcg/mL so it was 98.5% potent, thus meeting requirements. We then exposed the solution in a clear glass vial for 5 minutes under our lab’s typical florescent lighting, then once again tested it for potency. The potency was now at 54.4%, a 44.1% decline! Much of the active had converted to hydroxocobalamin (B12a). After another 5 minutes exposure, now a total of 10 minutes, the potency was now down to 30.8% a 67.7% decline from the initial potency. After a total of 15 minutes, the potency stood at 15.2%, a total decline of 83.3% from the starting point! Clearly, methylcobalamin is VERY light sensitive and easily converts to hydroxocobalamin."
Source: http://compounderslab.com/application/files/8715/4119/3589/Methylcobalamin_and_Light_10-18.pdf
I believe that Arnika's gross incompetence with regard to their production of MeB12 is absolutely the pharmaceutical industry standard worldwide. As a result, all injectable MeB12 sold on the market, even via prescription, is almost completely impotent.
In contrast, I had a source of MeB12 powder which I was able to mix with saline solution just prior to usage. This was extremely potent and gave me full health. By about the 10th day however, it would lose all potency despite light protection. My experience here (repeated dozens of times) goes against research saying that MeB12 is stable for 180 days once liquified.
My conclusions are:
Conclusion
I had a period of 9 months where I was able to obtain a very high quality MeB12 powder to which I would add saline when ready to use. I experienced full, robust health during these 9 months. I can no longer obtain this powder and the supplier has intensely refused to reveal where it came from and has claimed that the supplier went out of business during the pandemic.
I strongly suspect that the production of pure, sterile MeB12 for IM injection, has the potential to be a major healing agent for many people (possibly due to the CSF saturation that is enables), but that it is simply not available to the public. Furthermore, existing laws restrict the sale of this pure powder to pharmacies (compounding labs) who themselves do not know how to properly handle and produce a light protected, liquid form for injection.
"We manufacture the methylcobalamin ampoules in our clean rooms. These are of course protected from direct sunlight. We do not use any other special light protection during production. After production, the ampoules are packed in paper boxes and are therefore protected from sunlight. They should only be removed immediately before the injection."
I have a paper called Methylcobalamin and Light from Compounder's International Analytical Library (located in Colorado). In the paper, we find this paragraph:
"When formulating methylcobalamin, many are aware of its sensitivity to light but may not know just how sensitive it is. In our lab we carried out an experiment to see just how sensitive a typical formulation might be to typical interior lab lighting. The formulation we selected as our test sample was one containing methylcobalamin 1000 mcg/mL in normal saline plus benzyl alcohol 2%. We assayed the sample to check its potency and found it to be 985mcg/mL so it was 98.5% potent, thus meeting requirements. We then exposed the solution in a clear glass vial for 5 minutes under our lab’s typical florescent lighting, then once again tested it for potency. The potency was now at 54.4%, a 44.1% decline! Much of the active had converted to hydroxocobalamin (B12a). After another 5 minutes exposure, now a total of 10 minutes, the potency was now down to 30.8% a 67.7% decline from the initial potency. After a total of 15 minutes, the potency stood at 15.2%, a total decline of 83.3% from the starting point! Clearly, methylcobalamin is VERY light sensitive and easily converts to hydroxocobalamin."
Source: http://compounderslab.com/application/files/8715/4119/3589/Methylcobalamin_and_Light_10-18.pdf
I believe that Arnika's gross incompetence with regard to their production of MeB12 is absolutely the pharmaceutical industry standard worldwide. As a result, all injectable MeB12 sold on the market, even via prescription, is almost completely impotent.
In contrast, I had a source of MeB12 powder which I was able to mix with saline solution just prior to usage. This was extremely potent and gave me full health. By about the 10th day however, it would lose all potency despite light protection. My experience here (repeated dozens of times) goes against research saying that MeB12 is stable for 180 days once liquified.
My conclusions are:
- Most MeB12 available on the market is nearly worthless due to a simple lack of understanding of the light sensitivity of the molecule. This conclusion is backed by a major manufacturer today revealing that they think that keeping it out of sunlight is sufficient!
- Multiple health conditions that can be treated with high potency MeB12 go untreated do to this staggering incompetence in the pharmaceutical industry. For example, MS, CFS, Dementia and Alzheimer's. There are also anti-aging implications.
Conclusion
I had a period of 9 months where I was able to obtain a very high quality MeB12 powder to which I would add saline when ready to use. I experienced full, robust health during these 9 months. I can no longer obtain this powder and the supplier has intensely refused to reveal where it came from and has claimed that the supplier went out of business during the pandemic.
I strongly suspect that the production of pure, sterile MeB12 for IM injection, has the potential to be a major healing agent for many people (possibly due to the CSF saturation that is enables), but that it is simply not available to the public. Furthermore, existing laws restrict the sale of this pure powder to pharmacies (compounding labs) who themselves do not know how to properly handle and produce a light protected, liquid form for injection.
I can say a few things in reply: