Yes, I've made a great deal of improvement in working all of this. I was sleeping 16 hours a day and brain fogged and unable to think or do much with PEM and POTS, but now I sleep 8 to 9 hours a day, am clear headed most of the time, PEM is more rare, POTS is improving.
I've attacked this on multiple fronts. First, replenishing nutrients I was deficient in. My body uses huge quantities of B vitamins, antioxidants, lipids and amino acids. And working on my gut - I had no lactobacillus or bifidobacteria.
Then, working on my hormones and normalizing my sleep. I take thyroid, hydrocortisone, pregnenolone, progesterone, DHEA, and testosterone. And a sleep cocktail of aminos, magnesium, B6, etc.
Then, attacking infections, first holistically, and then after figuring out my immune system was broken, with LDN, antivirals, antibiotics, high doses of vitamin C, and oxygen therapies. I also get IV immunoglobulins to help and to work on the autoimmune antibodies causing POTS caused by the infections and am considering 10 Pass oxygen and Rituximab.
And I'm on a low carb, Paleo diet and exercise carefully, lifting weights and walking, to promote mitochondrial biogenesis.
It's a lot, but it's all helping. I found the attached model of treating CFS and found it helpful in explaining my abnormal lab results and the approach my doctors are using to help me - I have problems in every box in the chart.
Good luck in figuring out where you need to go in seeking a solution. This is a multi headed beast.