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I just wanted to suggest to whomsoever has viral/bacterial/microbial issues trying Olive Leaf Extract. I take it because I do not make enough stomach acid and stomach acid is the first line of defence against pathogens. I take 1g/day (Soloray). It makes me feel better all over, like maybe it reduced some subtle inflammation of my blood vessels.
If I don't take it for a week or so (maybe I ran out, maybe I got cheap) then I have gotton such things as felt-like-thrush and Olive Leaf Extract has cleared it right up within the hour.
One study showed it protects the beta cells of the pancreas from destruction (diabetes). It has been used to prevent colds and flu. According to Dr. James Duke, research ethnobotanist for the USDA responsible for the Phytochemical and Ethnobotanical Databases at the USDA (I met him in person at a wild plants convention!): it is a bacteriostat and an antioxidant, anti-arrhythmic, ace inhibitor, and vasodilator (so maybe that's why I like it so much as I have very very high blood pressure) : http://www.ars-grin.gov/duke/ (type oleuropein in where it asks for activities in a chemical)
it is hepatitis B antiviral : http://www.sciencedirect.com/science/article/pii/S0378874109004073
it and its hydrolysates inhibit 14 of 17 strains of lactic acid bacteria http://aem.asm.org/cgi/content/abstract/26/5/777
it inhibits haemorrhagic septicaemia virus: http://www.sciencedirect.com/science/article/pii/S0166354205000677
it's anti-angiogenic (anti-tumor) http://www.sciencedirect.com/science/article/pii/S0006291X05013409
It inhibits candida (but not as much as other pathogens and must be a high dose): http://www.ftb.com.hr/43/43-41.pdf
It fared unusually well against a host of major microbials that cause human disease (but no details - among listed was Candida): http://www.mdpi.com/1420-3049/12/5/1153
It inhibits aflatoxin growth (Paster et al. (1988) found that oleuropein reduced aflatoxin production, Gourama and Bullerman (1987), Paster et al. (1988) and Gourama et al. (1989) stated that oleuropein inhibited aflatoxin production) : http://www.sciencedirect.com/science/article/pii/0168160596011154 (you had to have the right search string to get that out of the pay-for-info paper)
A very interesting footnoted paper on oleuropein states : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002804/
5.5. Antimicrobial effect
Oleuropein has been shown to have strong antimicrobial activity against both Gram-negative and Gram-positive bacteria [5759] as well as mycoplasma [60]. Phenolic structures similar to oleuropein seem to produce its antibacterial effect by damaging the bacterial membrane and/or disrupting cell peptidoglycans. Different authors have used biophysical assays to study the interaction between oleuropein and membrane lipids [61]; however, the exact mechanism of the antimicrobial activity of oleuropein is still not completely established, although some authors have proposed that it is due to the presence of the ortho-diphenolic system (catechol) [57]. In 2001, Saija and Uccella [62] proposed that the glycoside group modifies the ability to penetrate the cell membrane and get to the target site. Effective interference with the production procedures of certain amino acids necessary for the growth of specific microorganisms has also been suggested. Another mechanism proposed is the direct stimulation of phagocytosis as a response of the immune system to microbes of all types.
Oleuropein and hydrolysis products are able to inhibit the development and production of enterotoxin B by Staphylococcus aureus, the development of Salmonella enteritidis and the germination and consequent development of spores of Bacillus cereus [5767]. Oleuropein and other phenolic compounds (p-hydroxybenzoic, vanillic and p-coumaric acids) completely inhibit the development of Klebsiella pneumoniae, Escherichia coli and B. cereus [58].Recently, Sudjana et al. [68] showed the antimicrobial activity of commercial Olea europaea (olive) leaf extracts (abundantly oleuropein) against Campylobacter jejuni, Helicobacter pylori and methicillin-resistant Staphylococcus aureus (MRSA). The authors also demonstrated these extracts play a role in regulating the composition of the gastric flora by selectively reducing levels of H. pylori and C. jejuni.
5.6. Antiviral effect
In a U.S. patent, it has been claimed that oleuropein has potent antiviral activities against herpes mononucleosis, hepatitis virus, rotavirus, bovine rhinovirus, canine parvovirus, and feline leukemia virus [69]. Studies have also shown that oleuropein exhibits a significant antiviral activity against respiratory syncytial virus and para-influenza type 3 virus [70].
...
The olive leaf extracts were investigated for their antiviral activity against viral hemorrhagic septicemia virus (VHSV), a salmonid rhabdovirus, and against HIV-1 infection and replication [72]. Cell-to-cell transmission of HIV was inhibited in a dose-dependent manner with EC50s of 0.2 ?g/ml, and HIV replication was inhibited in an in vitro experiment [73].
Well its not a study but it is interesting. Here is what one doctor says on his website: https://www.drhoffman.com/page.cfm/126
In 1962 an Italian researcher recorded that Oleuropein had the ability to lower blood pressure in animals. Other European researchers validated that claim and also found it to increase blood flow in the coronary arteries, relieve arrhythmia and prevent intestinal muscle spasms. In the years to come, a Dutch researcher identified that a primary ingredient in oleuropein inhibited the growth of viruses, bacteria, fungi and parasites. This chemical was elenolic acid. Further European research determined this compound to have strong bactericidal, antiviral and antifungal capabilities.
...
From research and clinical experience to date, we can say that supplemental olive leaf may be beneficial in the treatment for conditions caused by, or associated with, a virus, retrovirus, bacterium or protozoan. Among those treatable conditions are: influenza, the common cold, candida infections, meningitis, Epstein-Barr virus (EBV), encephalitis, herpes I and II, human herpes virus 6 and 7, shingles (Herpes zoster), HIV/ARC/AIDS, chronic fatigue, hepatitis B, pneumonia, tuberculosis, gonorrhea, malaria, dengue, severe diarrhea, and dental, ear, urinary tract and surgical infections.
Many people who live stressful lives or who may be particularly susceptible to colds and viruses may benefit from long-term use of olive leaf as a preventive agent. Some patients have expressed other unexpected benefits of olive leaf, including improved psoriasis, normalization of heart beat irregularities, diminished cravings, less pain from hemorrhoids, toothaches and chronically achy joints.
If I don't take it for a week or so (maybe I ran out, maybe I got cheap) then I have gotton such things as felt-like-thrush and Olive Leaf Extract has cleared it right up within the hour.
One study showed it protects the beta cells of the pancreas from destruction (diabetes). It has been used to prevent colds and flu. According to Dr. James Duke, research ethnobotanist for the USDA responsible for the Phytochemical and Ethnobotanical Databases at the USDA (I met him in person at a wild plants convention!): it is a bacteriostat and an antioxidant, anti-arrhythmic, ace inhibitor, and vasodilator (so maybe that's why I like it so much as I have very very high blood pressure) : http://www.ars-grin.gov/duke/ (type oleuropein in where it asks for activities in a chemical)
it is hepatitis B antiviral : http://www.sciencedirect.com/science/article/pii/S0378874109004073
it and its hydrolysates inhibit 14 of 17 strains of lactic acid bacteria http://aem.asm.org/cgi/content/abstract/26/5/777
it inhibits haemorrhagic septicaemia virus: http://www.sciencedirect.com/science/article/pii/S0166354205000677
it's anti-angiogenic (anti-tumor) http://www.sciencedirect.com/science/article/pii/S0006291X05013409
It inhibits candida (but not as much as other pathogens and must be a high dose): http://www.ftb.com.hr/43/43-41.pdf
It fared unusually well against a host of major microbials that cause human disease (but no details - among listed was Candida): http://www.mdpi.com/1420-3049/12/5/1153
It inhibits aflatoxin growth (Paster et al. (1988) found that oleuropein reduced aflatoxin production, Gourama and Bullerman (1987), Paster et al. (1988) and Gourama et al. (1989) stated that oleuropein inhibited aflatoxin production) : http://www.sciencedirect.com/science/article/pii/0168160596011154 (you had to have the right search string to get that out of the pay-for-info paper)
A very interesting footnoted paper on oleuropein states : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002804/
5.5. Antimicrobial effect
Oleuropein has been shown to have strong antimicrobial activity against both Gram-negative and Gram-positive bacteria [5759] as well as mycoplasma [60]. Phenolic structures similar to oleuropein seem to produce its antibacterial effect by damaging the bacterial membrane and/or disrupting cell peptidoglycans. Different authors have used biophysical assays to study the interaction between oleuropein and membrane lipids [61]; however, the exact mechanism of the antimicrobial activity of oleuropein is still not completely established, although some authors have proposed that it is due to the presence of the ortho-diphenolic system (catechol) [57]. In 2001, Saija and Uccella [62] proposed that the glycoside group modifies the ability to penetrate the cell membrane and get to the target site. Effective interference with the production procedures of certain amino acids necessary for the growth of specific microorganisms has also been suggested. Another mechanism proposed is the direct stimulation of phagocytosis as a response of the immune system to microbes of all types.
Oleuropein and hydrolysis products are able to inhibit the development and production of enterotoxin B by Staphylococcus aureus, the development of Salmonella enteritidis and the germination and consequent development of spores of Bacillus cereus [5767]. Oleuropein and other phenolic compounds (p-hydroxybenzoic, vanillic and p-coumaric acids) completely inhibit the development of Klebsiella pneumoniae, Escherichia coli and B. cereus [58].Recently, Sudjana et al. [68] showed the antimicrobial activity of commercial Olea europaea (olive) leaf extracts (abundantly oleuropein) against Campylobacter jejuni, Helicobacter pylori and methicillin-resistant Staphylococcus aureus (MRSA). The authors also demonstrated these extracts play a role in regulating the composition of the gastric flora by selectively reducing levels of H. pylori and C. jejuni.
5.6. Antiviral effect
In a U.S. patent, it has been claimed that oleuropein has potent antiviral activities against herpes mononucleosis, hepatitis virus, rotavirus, bovine rhinovirus, canine parvovirus, and feline leukemia virus [69]. Studies have also shown that oleuropein exhibits a significant antiviral activity against respiratory syncytial virus and para-influenza type 3 virus [70].
...
The olive leaf extracts were investigated for their antiviral activity against viral hemorrhagic septicemia virus (VHSV), a salmonid rhabdovirus, and against HIV-1 infection and replication [72]. Cell-to-cell transmission of HIV was inhibited in a dose-dependent manner with EC50s of 0.2 ?g/ml, and HIV replication was inhibited in an in vitro experiment [73].
Well its not a study but it is interesting. Here is what one doctor says on his website: https://www.drhoffman.com/page.cfm/126
In 1962 an Italian researcher recorded that Oleuropein had the ability to lower blood pressure in animals. Other European researchers validated that claim and also found it to increase blood flow in the coronary arteries, relieve arrhythmia and prevent intestinal muscle spasms. In the years to come, a Dutch researcher identified that a primary ingredient in oleuropein inhibited the growth of viruses, bacteria, fungi and parasites. This chemical was elenolic acid. Further European research determined this compound to have strong bactericidal, antiviral and antifungal capabilities.
...
From research and clinical experience to date, we can say that supplemental olive leaf may be beneficial in the treatment for conditions caused by, or associated with, a virus, retrovirus, bacterium or protozoan. Among those treatable conditions are: influenza, the common cold, candida infections, meningitis, Epstein-Barr virus (EBV), encephalitis, herpes I and II, human herpes virus 6 and 7, shingles (Herpes zoster), HIV/ARC/AIDS, chronic fatigue, hepatitis B, pneumonia, tuberculosis, gonorrhea, malaria, dengue, severe diarrhea, and dental, ear, urinary tract and surgical infections.
Many people who live stressful lives or who may be particularly susceptible to colds and viruses may benefit from long-term use of olive leaf as a preventive agent. Some patients have expressed other unexpected benefits of olive leaf, including improved psoriasis, normalization of heart beat irregularities, diminished cravings, less pain from hemorrhoids, toothaches and chronically achy joints.