Hello,
I am newbie to this group. I would like to first say that, I really impressed with the amount of information/experiences you guys share and it helped me understand lot of things. I wouldn't have restarted my B12 and Folic acid supplements again in proper way, if I wouldn't find this forum. Thank you
I am almost sure that I have some kind of B12 or/and Folic acid or/and D3 issues but need to understand what exactly causing or which one is impacting more. I really need some help to understand this.
Here is my story, will try to make it simple.
Symptoms (higher to lower troublesome)
1) Headaches (nor migraines neither tension headaches), all over nerve pains on head and face. Almost 24/7, fluctuate throughout the day.
2) No refreshing sleep
3) Anxiety, tingling legs and hands
4) Fatigue
5) Depression
6) Insomnia
7) Gastro issues (Constipation/Diarrhea, Bloating)
8) Irritable mood
9) Brain fog
Having these symptoms from past 15 years
Diagnostics/Medicines tried which didn’t help/normal :
1) MRI ,Eye test, Colonoscopy, Endoscopy, TMT/bruxism, sleep study, nerve pinching on neck test were normal
2) Different SSRI’s and Anti seizure medications. Nothing worked.
3) Cognitive behaviours therapy (it helped bit with my worry thoughts)
Diagnostics abnormal and medicines worked
1) Homocysteine(umol/L) (2011 : 20+, 2014 : 14.69, 2016: 12.8),
D3(ng/ml) (2011 : 9, 2014 : 28.7, 2016 : 19)
2) In 2011, tried
Methycobalamin shots one per day for one month (didn’t remember dosage)
D3 powder once per week (50,000IU)
This make most of my symptoms reduced to 70% and then was stopped working after 20 days while still taking B12 shots and D3. I guess the reason is B12 shots may have been exposed to light. I didn’t understand why it stopped working at that time and thought its not related to B12 and D3
3) A recent Methylmalonic acid test was 0.4 umol/L (range 0.0 umol/L to 0.3 umol/L), not sure this implies B12 deficiency. (my assumption is B12 is OK but folic acid has problem)
4) Currently using Thorne 5-mthf 1 mg and Jarrow 5mg B12 sublingual.(from past few days)
This make my symptoms reduced to 95%
D3 started few weeks back, every week 50,000IU. But no immediate results when I started.
23AndMe results (Mutations from geneticgenie)
VDR Taq AA +/+
MAO A R297R T +/+
ACAT1-02 AG +/-
MTHFR 03 P39P AA +/+
MTHFR A1298C GG +/+
MTR A2756G AG +/-
MTRR A66G AG +/-
MTRR A664A AG +/-
BHMT-02 CT +/-
BHMT-08 CT +/-
CBS A360A AG +/-
The information on these SNPs is too overwhelming to me and I am unable to get a conclusion about whats happening with my methylation cycle based on above mutations. I am also not sure if I have CFS because I never been bed ridden and never had debilitated by body pains/Fatigue like I saw in most of the users posted in this forum but definitely effected my quality of life highly. I am 35 years old IT Engineer and I am OK (I could have done much better with out this condition but currently I am not bad) in my career except that I am experiencing/suffering with this health condition. I consulted a lot of doctors and no one really helped me.
It would be nice to if guys share your insight on my symptoms and whether I am deficient on B12 or folic acid or may be something else ?
The effects of B12/Folic acid supplements on me is super powerful that now I am more calm, patient and able to enjoy things in my life.
I am also wondering that B12/Folic acid supplements shows such a strong effect that make my symptoms disappear almost in few hours. Is that the way they work ?
Thanks a lot of reading this.
Sri
I am newbie to this group. I would like to first say that, I really impressed with the amount of information/experiences you guys share and it helped me understand lot of things. I wouldn't have restarted my B12 and Folic acid supplements again in proper way, if I wouldn't find this forum. Thank you
I am almost sure that I have some kind of B12 or/and Folic acid or/and D3 issues but need to understand what exactly causing or which one is impacting more. I really need some help to understand this.
Here is my story, will try to make it simple.
Symptoms (higher to lower troublesome)
1) Headaches (nor migraines neither tension headaches), all over nerve pains on head and face. Almost 24/7, fluctuate throughout the day.
2) No refreshing sleep
3) Anxiety, tingling legs and hands
4) Fatigue
5) Depression
6) Insomnia
7) Gastro issues (Constipation/Diarrhea, Bloating)
8) Irritable mood
9) Brain fog
Having these symptoms from past 15 years
Diagnostics/Medicines tried which didn’t help/normal :
1) MRI ,Eye test, Colonoscopy, Endoscopy, TMT/bruxism, sleep study, nerve pinching on neck test were normal
2) Different SSRI’s and Anti seizure medications. Nothing worked.
3) Cognitive behaviours therapy (it helped bit with my worry thoughts)
Diagnostics abnormal and medicines worked
1) Homocysteine(umol/L) (2011 : 20+, 2014 : 14.69, 2016: 12.8),
D3(ng/ml) (2011 : 9, 2014 : 28.7, 2016 : 19)
2) In 2011, tried
Methycobalamin shots one per day for one month (didn’t remember dosage)
D3 powder once per week (50,000IU)
This make most of my symptoms reduced to 70% and then was stopped working after 20 days while still taking B12 shots and D3. I guess the reason is B12 shots may have been exposed to light. I didn’t understand why it stopped working at that time and thought its not related to B12 and D3
3) A recent Methylmalonic acid test was 0.4 umol/L (range 0.0 umol/L to 0.3 umol/L), not sure this implies B12 deficiency. (my assumption is B12 is OK but folic acid has problem)
4) Currently using Thorne 5-mthf 1 mg and Jarrow 5mg B12 sublingual.(from past few days)
This make my symptoms reduced to 95%
D3 started few weeks back, every week 50,000IU. But no immediate results when I started.
23AndMe results (Mutations from geneticgenie)
VDR Taq AA +/+
MAO A R297R T +/+
ACAT1-02 AG +/-
MTHFR 03 P39P AA +/+
MTHFR A1298C GG +/+
MTR A2756G AG +/-
MTRR A66G AG +/-
MTRR A664A AG +/-
BHMT-02 CT +/-
BHMT-08 CT +/-
CBS A360A AG +/-
The information on these SNPs is too overwhelming to me and I am unable to get a conclusion about whats happening with my methylation cycle based on above mutations. I am also not sure if I have CFS because I never been bed ridden and never had debilitated by body pains/Fatigue like I saw in most of the users posted in this forum but definitely effected my quality of life highly. I am 35 years old IT Engineer and I am OK (I could have done much better with out this condition but currently I am not bad) in my career except that I am experiencing/suffering with this health condition. I consulted a lot of doctors and no one really helped me.
It would be nice to if guys share your insight on my symptoms and whether I am deficient on B12 or folic acid or may be something else ?
The effects of B12/Folic acid supplements on me is super powerful that now I am more calm, patient and able to enjoy things in my life.
I am also wondering that B12/Folic acid supplements shows such a strong effect that make my symptoms disappear almost in few hours. Is that the way they work ?
Thanks a lot of reading this.
Sri