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Lactobacillus and Mental Health

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Wishful

Senior Member
Messages
5,751
Location
Alberta
https://newatlas.com/health-wellbei...lus-microbiome-immune-response-mental-health/

I thought this was interesting. They found that stress decreases lactobacillus population, which reduces interferon-gamma, which in turn leads to mood disorders.

I don't know how correct the findings are, but it should encourage more studies into gut/mind interaction. FWIW, I think elevated IFN-g made my symptoms worse, which was the opposite of reducing depression. PEM is depressing!
 
perchance dreamer

perchance dreamer

Senior Member
Messages
1,699
I haven't tried these products, but Garden of Life has 2 probiotics for mood, developed by the neurologist David Perlmutter: Mood Daily Care and Mood Plus. The 1st ten ingredients for each are different forms of lactobacillus.

The fatty acid DHA , found in cold water fish, helps me with mood. I take the Nordic Naturals brand.
 
D

datadragon

Senior Member
Messages
398
Location
USA
Hi Wishful, the issue is that the body switches like a see-saw into an inflammatory state. This leads to the leaky gut and changes in the microbiome composition and function toward a more inflammatory state including the reduction in lactobacillus population as part of that, increased propionate and decreased butyrate, and alongside that within the brain are signs of neuroinflammation in the research I have, so its all linked together actually.

Other research has looked into specific functions of certain gut species. One that I have mentioned before for example, Lactobacillus reuteri, a species with decreased relative abundance in the Shank3 Knockout mice (which leads to the impaired gut barrier and changes in the microbiome composition toward the inflammatory state), positively correlated with the expression of gamma-Aminobutyric acid (GABA) receptor subunits in the brain. https://forums.phoenixrising.me/thr...-on-right-side-may-be-best.89827/post-2441279

Lactobacillus sp. strain E1 catalyzed the decarboxylation of glutamate (Glu), resulting in a nearly stoichiometric release of the products gamma-aminobutyrate (GABA) and CO2. This decarboxylation was associated with the net synthesis of ATP, so this decarboxylation process can be coupled with energy production https://pubmed.ncbi.nlm.nih.gov/9150237/
 
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