Nila, I realized in retrospect that I'd gotten into overmethylation, twice. Once from too much methylB12, the other from too much folate. In each case I'd raised one without the other. And in both cases I had histamine response, which is one of my ongoing symptoms. These involved rash on my scalp and heavy hair loss. Here are a few links to issues from Freddd's Protocol. His posts can be very dense, I've had to reread them countless times, but that's where I've found my support and answers. The 4 components of his Deadlock Quartet have proven essential for me to improve.
THE COMPLETE METHYLATION REVIEW Fredd Feb 2013 [very long and involved]
http://forums.phoenixrising.me/index.php?threads/the-stages-of-methylation-and-healing.21725/
http://forums.phoenixrising.me/inde...t-hole-insufficiency.22614/page-2#post-345537
http://forums.phoenixrising.me/inde...kalemia-and-methylfolate-insufficiency.22968/ [re B vits, K+...]
http://forums.phoenixrising.me/inde...e-anger-or-agitation.15837/page-3#post-352974
@ahmo, what did you do when you got overmethylated/a histamine response?
I started the Freddd protocol 1.5 weeks ago on Saturday. For the first couple of days I felt good: increased energy, decreased MCS but not nervous/anxious/ADD-like like I do when I have a mast cell/histamine response. (This can be very severe with me as I have a diagnosed Mastocytosis by biopsy.) However, I had huge issues with mucus/sinus issues/felt like I had a massive cold which I haven't had in years.
I took tiny crumbs of B Complex by pure encapsulations at the time plus around 50 mcg MB12 plus increased my Mfolate dosage from 3 times 400 mcg to 4 times 800 mcg during that time. I got increasing histamine/mastocytosis symptoms during that time. For me, that is migraine-like headaches, light intolerance, ravenous appetite, racing heart, excess saliva, lump in throat/swollen throat, nasal congestion and massive edema (like I told you in another thread, I'd gained 6 kg of water(?) within the first week), nervousness, ADD-like behaviour, whiney etc. which all responds to H1 antihistamine (Desloratadine) medication.
I have now stopped supplements completely (last MFolate the night before last night) because it just got too out of control and I didn't know what else to do as I can't tolerate Niacin well for stopping it (I flush in seconds). However, I am still so overmethylating/having such a large mast cell degranulation that I am on my antihistamine medication constantly to make it bearable.
So I'm wondering how to stop this overmethylation madness?!
What I do notice, however, is that even the past few days of methylation have made SUCH a big difference:
For instance,
- my digestion has improved/when I've got gas in my large intestine, I don't feel completely liver-toxic (like THE worst hangover ever, cannot speak properly, fall asleep randomly) anymore
- felt more stable, at least in the first few days: physical activity was way less exhausting
- in a good/stable mood (until the massive histamine response came up), great mental clarity (since histamine response: over-alert/anxious)
- MCV went from 110 to 90 =)
- No raised eosinophiles/basophiles for the first time in 2 yrs (STRANGE, always assumed this was a sign of my mastocytosis but then !!)
So I think methylation is something for me/my issue but I am wondering how to find a balance? I'm 26 and I live on my own in Germany and it was really scary to bear all the overmethylation symptoms without any advice apart from this WONDERFUL(!) forum around... from reading around I thought that maybe the AdenoB12+Mfolate would be a suitable as the functions of AdenoB12 are, according to Freddd:
1. mitochondria at the heart of ATP production
2. processing fatty acids for myelin generation for healing nerves
3. anti-inflammatory: with zinc it a complete fix for the inflammation and NO with no nasty leftovers like HyCbl leaves behind.
So it's not really involved in methylation if I get this right. But then, without the MB12, that's not really Freddd's protocol anymore, who suggests
I suggest establishing Methylation startup with 100+ mcg of MeCbl and AdoCbl absorbed each (at least, since the effect is NOT linear, 80% of all the body healing that can turn on does with a couple of hundred absorbed mixed active B12s. One ENZY tablet and part of an Anabol Dibencoplex capsule along the lip and gum for 1-2 hours is quite sufficient until potassium and L-methylfolate are titrated to full need at that level, then tolerate the LCF.
So I am wondering if anyone has tried this? Or are there any reasons not to try this? I.e. titrate up to 100 mcg AdenoB12 and some Mfolate (the question being how much as this would not really be Freddd's protocol anymore and other protocols seem to be going for something like 200 mcg rather than loads, hm!)? I also have LCF and SAMe sitting about, which I have not come around to try yet, and Potassium.
It's just that I completely voerreact to MB12 and B-Complex each time I take it...
Also, coming back to the topic of this thread (oopsie!), since I have been alone with this (for more information see
http://forums.phoenixrising.me/inde...ol-vs-lab-results-vs-systemic-response.39156/ ), an American family friend wants to support me.
So I am looking for an
experienced practitioner who works with international clients (Germany) over skype, who is very familiar with methylation/gut issues and histamine/mast cell involvement, plus
lab tests that can give me additional insight on what I need. I already have done gut dysbiosis testing (bad result with mainly just Clostridum Spp. in there but I have been working on that and feel that if I leave out any protein/sulfur containing food i.e. stick to a diet of cooked sweet potato, carrots, oils, pumpkins and squashes, asparagus, and, when I am not on a methylation protocol, lettuce, fennel, courgettes [I know vege has some protein in it but I am ok on it], I don't get endotoxic bloating=>liver symptoms and inflammation plus I go to the toilet nice and regularly plus manage to gain weight), and the 23andme test as can be seen in the thread above.
I was thinking of doing the Nutreval test and then I was going to have a look at the links you,
@caledonia, suggested here
If you feel like you need a doc to help manage things, you can try one of the docs at
MTHFRsupport.com. Dr. Jess Armine, Sean Bean (nutritionist, not doc, but supposed to be very knowledgeable), Dr. Tim Jackson and few others do phone or Skype consults. The rate is something like $250 per hour, which will, of course, vary by practitioner.
http://www.mthfrsupport.com/practitioner-2/united-state/
http://www.mthfrsupport.com/pennsylvania/
http://www.mthfrsupport.com/south-carolina/
As the links aren't working, I was wondering whether these are just the links to Dr. Jess Armine, Sean Bean (nutritionist, not doc, but supposed to be very knowledgeable), Dr. Tim Jackson , respectively?
It'd be SO nice to have someone guide me through this and I am happy to pay for it. So please let me know any suggestions you have for my case — both tests and practitioners that work via skype!
Thanks a LOT for sharing your knowledge on this!!
Best wishes and, most importantly, much health and patience to all of you,
Frchli