Martial@
I think its important to address the multi level issues that come with chronic illness and find Radio does it perfectly. I have also seen some other response citing that he did not have CFS or that it seems to not benefit for some others. In this case it is important that we look into all possibilities for disease. Radio discusses dysbiosis and mito dysfunction however there are issues for methylation mutations that could be looked into, chronic infections that are hard to catch like Lyme and Co, Parasitic, Viral loads, etc.. Then you have the inflammatory immune response markers that need to be brought into check, deficiencies of vitamins and minerals which can be incredibly taxing on the body and cause all kinds of vicious dysfunctions as well. Toxicities, allergens, heavy metals, etc..
Keep in mind as well that as long as a chronic infection is present there will be dysfunction until it is brought under control.. You could be making all the corrections in the world but as long as it is not dealt with there can't be full recovery even with everything else in place, this is because it will block those enzymes, vitamins, minerals, and physiological functions from its normal functions and homeostasis of the body. There are many, many components in chronic disease so the search for a single underlying cause may not show the same source of trigger into disease for everyone, and is not the only thing to be addressed. Though I think finding a source of dysfunction in the first place is extraordinarily useful and as of now I have huge suspect of methylation issues that make one pre disposed.