My detoxification does not work properly, testing revealed that my methylation pathway is not the problem, something else is: I was recently diagnosed with a sulphuration problem; my sulphuration detox pathways are impaired. I think that this may be a problem for many PWC, therefore my story: My blood test indicate a Sulhoxidization / sulphur metabolism problem. Firstly I seem to have a problem with the pst enzyme ((phenol- sulfotransferase), this is suggested by my high DHPPA level. Secondly I seem to fail to transform sulfur in sulfate. This is suggested by my high cystathione and high Cysteine. My high cysteine shows I cannot make this step, it transforms in the toxic cysteine. I also have low glycine and L-histidine, these are required for this sulphur metabolism. This sulphoxidation problem may well be responsible for many my food intolerances for foods that contain salicylate and also my chlorine intolerance (this is a pst inhibitor). For information see http://www.newtreatments.org/fromweb/sulfur.html (NOTE: THIS IS VERY HARD TO READ, I TRIED TO SUMMARIZE IT (+SOME ADDITIONS )IN POST #8) Treatment: take glycine, topical epsom salt cream, natural vitamin A (cod liver oil), and vitamin K2 to help sulphuroxidization. Avoid salycilate rich foods and in particular banana and chocolate as these are PST inhibitors.