thegodofpleasure
Player in a Greek Tragedy
- Messages
- 207
- Location
- Matlock, Derbyshire, Uk
In 2007, Dr John Chia published a paper which showed that a high proportion of M.E patients were found to have a viral protein (VP1) expressed in biopsies taken from the tissues lining their stomachs. That paper can be found here: http://jcp.bmjjournals.com/content/61/1/43.abstract and the full version is also available in the Library: http://forums.phoenixrising.me/inde...ated-with-chronic-enterovirus-infection.3097/
Dr Chia & colleagues have now followed up that work with a new paper entitled "Functional Dyspepsia and Chronic Gastritis associated with Enteroviruses" a full version of which can be accessed here: https://app.box.com/s/tzqw9bu7w48rd037jvmlyzmbr3pedo7g
Having failed to capture the interest of the scientific community with his earlier work, Dr Chia has played down the "CFS" angle in the title of the paper and in finding the same rates of infection in Functional Dyspepsia patients, will engage with a much broader audience in the world of gastroenterology.
This could therefore be huge for us !
If you look at the Wikipedia page on Double-stranded RNA viruses http://en.wikipedia.org/wiki/Double- stranded_RNA_viruses and then follow some of the leads - for example to "DICER" http://en.wikipedia.org/wiki/Dicer, it doesn't take too much imagination to see that a genetic defect in the DICER1 gene could be at the root of the problem - both in FD/ Chronic Gastritis and in M.E. ........ the difference being that PwME go on to develop additional autoimmune problems.
Dr Chia & colleagues have now followed up that work with a new paper entitled "Functional Dyspepsia and Chronic Gastritis associated with Enteroviruses" a full version of which can be accessed here: https://app.box.com/s/tzqw9bu7w48rd037jvmlyzmbr3pedo7g
Abstract
After decades of research, functional dyspepsia (FD) remains one of the most elusive gastrointestinal
disorders. Endoscopic appearance of mild inflammation of the gastric mucosa without ulceration
and microscopic evidence of mild chronic inflammation are often considered as normal
findings since no etiology could be found other than H. pylori. Enteroviruses infect the gastrointestinal
tract and have been shown to persist in the stomach of symptomatic patients with myalgic
encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, we evaluated FD patients
with and without the diagnosis of ME/CFS, and were able to support the viral protein staining with
finding of double-stranded RNA in 63% of the same stomach biopsies by immunoperoxidase
staining. Furthermore, we clarified the possible cross-reaction with creatine kinase brain subtype
(CKB), present in parietal cells, using antibody competition experiments and western blot analysis
of stomach proteins. Viral protein+ and dsRNA+ biopsies were infectious in SCID mice. More research
is needed to elucidate the mechanism of enterovirus infection of the stomach associated
with FD and chronic gastritis.
Having failed to capture the interest of the scientific community with his earlier work, Dr Chia has played down the "CFS" angle in the title of the paper and in finding the same rates of infection in Functional Dyspepsia patients, will engage with a much broader audience in the world of gastroenterology.
This could therefore be huge for us !
If you look at the Wikipedia page on Double-stranded RNA viruses http://en.wikipedia.org/wiki/Double- stranded_RNA_viruses and then follow some of the leads - for example to "DICER" http://en.wikipedia.org/wiki/Dicer, it doesn't take too much imagination to see that a genetic defect in the DICER1 gene could be at the root of the problem - both in FD/ Chronic Gastritis and in M.E. ........ the difference being that PwME go on to develop additional autoimmune problems.