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After starting the methylation protocol about 3 years ago, I’ve made some significant progress and steps forward in health. I'm no longer bound to the house, but I am at another roadblock so I’m creating this post to get feedback as to how to overcome it.
My specific problem with the protocol is certain things (EDIT: result in muscle wasting, teeth/gum wasting, and exhaustion. The effect is quick, beginning within minutes to a day when I really notice it. Now that I consider it further, it may initiate with scavenging of Nitros Oxide because of how quickly it happens). If think the first 3 are most relevant to my current situation in this list, but I'm including the other 3 for perspective:
I never got to try SAMe, which I’m considering trying again, but the mood warnings kind of freak me out because I get anxiety and I don’t like all of the extra ingredients in the NatureMade brand.
On to what’s worked: after a long process of trial and error I got to a plateau with these daily supps about 6 months ago:
With these supplements after I plateaued, I wasn’t getting worse, but I wasn’t getting better. 6 months ago I switched to the carnivore diet with regular fasting and time-restricted eating to quell joint stiffness issues, and it worked for the most part. However I noticed a general fatigue/depression starting in again recently. My annual physical showed low folate for the first time ever, so I decided to try introducing supplements again after the doc recommended methylfolate. I had put most of my methylation supplements on hold because I was only eating fatty meat and fatty fish, and B vitamins don’t absorb well with this. After about a week of going back on them, I tried methylfolate again.
Here’s the problem. Methylfolate has the same damn effect as it did before. Anxiety, muscle wasting, teeth sensitivity. I cannot have this as my health is too close to the precipice. It’s the same feeling I get with acetyl l carnitine.
My muscles get weak and tight and I get anxiety and I start to crave sugar/carbs, which help but they increase inflammation. It’s like ATP ramps up and then runs out of something and keeps ramping up, and if I feed it what my body craves my joints get stiffer.
Any ideas on what I’m missing? My next thoughts are:
I’m really confused on this one :-/
My specific problem with the protocol is certain things (EDIT: result in muscle wasting, teeth/gum wasting, and exhaustion. The effect is quick, beginning within minutes to a day when I really notice it. Now that I consider it further, it may initiate with scavenging of Nitros Oxide because of how quickly it happens). If think the first 3 are most relevant to my current situation in this list, but I'm including the other 3 for perspective:
- Adenosylcobalamin causes a run down feeling, muscle and gum wasting, and my teeth get dry, yellow, and extremely sensitive. I have low bone density so this is a serious issue for me. Even with low doses I start to look like a meth addict. I tolerated this well in the first 2 weeks, since I have discontinued it due to the side effects.
- Methylfolate (metafolin) caused a run down feeling, muscle wasting, anxiety and a dry, scratchy throat.
- Carnitine in tiny doses feels like it overrevs my system then I get extended fatigue and muscle wasting.
- ...
- Trace Minerals Complex II causes a feeling that my liver is shutting down, takes days/weeks to get out of my system. Stop eating and get fatigued.
- Trace Minerals No Muscle Cramps causes brainfog, anxiety, and it feels like I’m slow to process it in VERY small amounts: 2 mg magnesium, 10 mg chloride, 4 mg sodium, 5 mg potassium, 1 mg sulfate. I stop urinating as much as I should and get fatigued and stop eating.
- Calcium: I am not producing enough stomach acid to absorb calcium to increase bone density, which I believe is part of the methylation problem I face. Small calcium doses cause extended constipation which stop me from eating.
I never got to try SAMe, which I’m considering trying again, but the mood warnings kind of freak me out because I get anxiety and I don’t like all of the extra ingredients in the NatureMade brand.
On to what’s worked: after a long process of trial and error I got to a plateau with these daily supps about 6 months ago:
- · 1200 mg Alpha GPC (choline)
- · 1000-3000 mcg Hydroxycobalamin (metabolix brand liquid - yes it's good and I know I absorb it)
- · 6000-8000 IU Vitamin D
- · 500 mg Panthothenic Acid
- · 17 mg Riboflavin 5 Phosphate
- · 20 mg Benfotiamine
- · 50 mg P5P
- · 800 mcg Biotin
- · 300 mg Magnesium
- · 3-4 g Pharmaceutical grade through fish oil and caviar
- · 2000 mg Vitamin C
With these supplements after I plateaued, I wasn’t getting worse, but I wasn’t getting better. 6 months ago I switched to the carnivore diet with regular fasting and time-restricted eating to quell joint stiffness issues, and it worked for the most part. However I noticed a general fatigue/depression starting in again recently. My annual physical showed low folate for the first time ever, so I decided to try introducing supplements again after the doc recommended methylfolate. I had put most of my methylation supplements on hold because I was only eating fatty meat and fatty fish, and B vitamins don’t absorb well with this. After about a week of going back on them, I tried methylfolate again.
Here’s the problem. Methylfolate has the same damn effect as it did before. Anxiety, muscle wasting, teeth sensitivity. I cannot have this as my health is too close to the precipice. It’s the same feeling I get with acetyl l carnitine.
My muscles get weak and tight and I get anxiety and I start to crave sugar/carbs, which help but they increase inflammation. It’s like ATP ramps up and then runs out of something and keeps ramping up, and if I feed it what my body craves my joints get stiffer.
Any ideas on what I’m missing? My next thoughts are:
- force myself to try calcium/strontium again with the magnesium, though this always left me exhausted, depressed and constipated
- Switch methylfolate to Folinic Acid
- Take higher doses (Freddd recommended levels) of potassium despite the anxiety/brain fog/detached feeling it causes (EDIT: potassium also causes stiffness in the skeletal muscles/joints. I haven't isolated it yet, but when I take potassium supplements it gets much harder for me to move).
- Try SAMe despite the ingredient concerns
- Try L-ornithine again despite it always causing cold sores
I’m really confused on this one :-/
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