Thanks to reading the great advise to others on here about 23 and Me, I also had my 23andme test done, though I have absolutely no clue at all :thumbdown: can anyone shed any light on these at all? if I can get them to show that is... I wasn't sure which results to show... the methylation or detox? the one below is the methylation.
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You have two First Priority mutations ACAT and CBS. ACAT is one of the "leaky gut" genes. This doesn't mean that for sure you have leaky gut, but if you have many food allergies/intolerances, or you start getting into a very high need for potassium or magnesium when you start methylation, you should suspect leaky gut and treat that first. The other thing about ACAT is it can cause kidney stones because it affects the bile. You can take ox bile/bile salts to counteract that, and also do a low oxalate diet.
The next mutation to check is CBS. If you have high urine sulfate and/or ammonia, and you have trouble tolerating methylation supplements such as getting a stress/anxiety response, you will need to treat CBS first. The Heartfixer page has comprehensive info on how to do that.
Then you pretty much have a green light to treat methylation. For sure get some methylfolate for the MTHFR C677T. MTRR is B12 recycling. You have some limitations there, but not horrible, so I'm not sure if you'll need B12 supplementation or not. Some functional testing should be helpful to determine that. If you're taking methylfolate, you might need a bit of B12 to make sure you don't get methyl trapping.
VDR Taq +/- may have small impact on which kind of B12 to take. Yasko says to take methylcobalamin, some hydroxycobalamin, and adenosylcobalamin. I have the same SNPs and am doing ok with methyl, adenosyl and no hydroxy, but my doses are very low.
The last one is VDR Bsm, which is Vitamin D receptor. You should get your vitamin D levels checked and supplement with that if it's low.
Check out the links in my signature for more info.