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Some informational links about Methylation and B12

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Bluebell, Jun 28, 2013.

  1. Bluebell

    Bluebell Senior Member

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    Informational Links about Methylation
    as of October 8, 2013

    In case it might be of interest, below is a list of informational links about methylation that I have collected this year.

    There are some disagreements amongst the experts/authors regarding the details, hypotheses, treatments, outcomes, etc. I have tried to include various points of view. I'm sure there are other experts/authors in the area of methylation whose work I have not run across yet online, and that would be the only reason that they were not on the list.

    CONTENTS:
    1. Articles, Presentations, and Videos about Methylation
    2. Genetic Testing Resources
    3. Programs that Analyze an Individual's 23andMe Genetic Data

    A personal note:
    While I understand some basics about genetics and nutrition, I do not have any knowledge of biochemistry. The topic of methylation is new and unintuitive to me, while it's apparent that many participants of PhoenixRising can mentally picture these interlocking bodily systems actually moving dynamically in time, with shortages and excesses building up, paths being closed off, other far-flung physical processes impinging, etc. I can do that with some other topics, but this one eludes me. The methylation diagrams look to me like a basket of yarn that a kitten has gotten into, and then spilled a box of alphabet-letters pasta on top of! :lol: If you feel similarly, do not be discouraged. Just grasp what you can, in your own time. The brief videos that Phoenix Rising member Caledonia created (see below for the link) might be a good first overview.

    ///////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////

    1. ARTICLES, PRESENTATIONS, AND VIDEOS ABOUT METHYLATION

    ===
    Audhya, Dr. Tapan, Health Diagnostics and Research Institute (formerly Vitamin Diagnostics)
    Role of B Vitamins in Biological Methylation - document
    http://www.hdri-usa.com/assets/files/role_of_b_vitamins_in_biological_methylation.pdf

    Audhya, Dr. Tapan, Health Diagnostics and Research Institute (formerly Vitamin Diagnostics)
    Description of Methylation and contents of the Methylation Pathway Panel (Test) - article
    http://www.hdri-usa.com/tests/methylation/

    ===
    Bense, Helen Janneson (of Insight Naturopathy)
    MTHFR A1298C Polymorphism - article
    https://www.facebook.com/notes/insight-naturopathy/mthfr-a1298c-polymorphism/385764944792649

    ===
    Caledonia, member of PhoenixRising @caledonia
    Methylation Made Easy: parts 1,2,3,4 - videos
    http://www.youtube. com/watch?v =o4uqEDK6BvM (to watch, take out the spaces in front of "com" and "=")
    (Note: The following link is to a version of the videos with no background music, but Caledonia has written that only the ones with music will be kept updated over time: http://www.youtube. com/watch?v =o5012ySbXaQ)

    ===
    Escott-Stump, Sylvia
    Systemic Nutrition-What's Your Gut Reaction? - presentation
    http://thescholarship.ecu.edu/handle/10342/2141

    ===
    Freddd, member of PhoenixRising @Freddd
    The Stages of Methylation and Healing - forum discussion
    http://forums.phoenixrising.me/index.php?threads/the-stages-of-methylation-and-healing.21725

    Freddd, member of PhoenixRising
    Active B12 Protocol Basics - forum discussion
    http://forums.phoenixrising.me/index.php?threads/active-b12-protocol-basics.10138

    Freddd, member of PhoenixRising
    Many other PhoenixRising threads
    http://forums.phoenixrising.me/index.php?search/8715836

    Freddd, member of PhoenixRising, and Dr. Rich van Konynenburg
    Differences between Freddd's protocol and the Simplified Treatment Approach (as of April 2011) - forum discussion
    http://forums.phoenixrising.me/inde...to-methylation-block-theory.9791/#post-178851 (start at this post and continue reading through the next two posts after this one)

    ===
    Garilli, Dr. Bianca
    MTHFR Mutation: A Missing Piece in the Chronic Disease Puzzle - article
    http://holisticprimarycare.net/topi...a-missing-piece-in-the-chronic-disease-puzzle

    ===
    Hyman, Dr. Mark
    Glutathione - article
    http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html

    ===
    Kresser, Chris
    B12 Deficiency part 1 - article
    http://chriskresser.com/b12-deficiency-a-silent-epidemic-with-serious-consequences

    Kresser, Chris
    B12 Deficiency (with simple methylation protocol) part 2 - article
    http://chriskresser.com/what-everyone-especially-vegetarians-should-know-about-b12-deficiency

    ===
    Lynch, Dr. Ben
    Methylation Defects and MTHFR - video
    http://www.seekinghealth.com/natural-health-video/methylation-defects-and-mthfr.html

    Lynch, Dr. Ben
    various topics - podcasts
    http://www.seekinghealth.com/learning-center

    Lynch, Dr. Ben
    website devoted to issues around MTHFR
    http://mthfr.net/

    ===
    McQueen, Deborah A
    Methylenetetrahydrofolate Reductase Polymorphism in the Etiology of Ehlers-Danlos Syndrome, Hypermobility Type: Connecting the Dots - article
    http://www.mthfrheds.com

    ===
    Life Extension organization
    Some of the relevant supplements (discussed in the context of reducing homocysteine) - articles
    http://www.lef.org/protocols/heart_circulatory/homocysteine_reduction_02.htm?source=search&key=mthfr
    http://www.lef.org/magazine/mag2009...aking-You-Sick_01.htm?source=search&key=mthfr

    ===
    Morissette, Dr. Debbi Ann
    Psychiatric Disorders: A Messed Up MTHFR - article
    http://cdn.neiglobal.com/content/blog/messed_up_mthfr.pdf

    ===
    Myhill, Dr. Sarah
    The Methylation Cycle - article
    http://drmyhill.co.uk/wiki/CFS_-_The_Methylation_Cycle

    ===
    Nathan, Dr. Neil
    Q&A on the Simplified Methylation Protocol (he was a research partner of Dr. Rich van Konynenburg) - article
    http://www.prohealth.com/library/showarticle.cfm?libid=16338

    Nathan, Dr. Neil
    What is the Methylation Protocol (he was a research partner of Dr. Rich van Konynenburg) - article
    http://www.gordonmedical.com/unravelling-complex-chronic-illness/what-is-themethylation-protocol

    Nathan, Dr. Neil
    Supplements in the methylation protocol (this is the same protocol as Dr. Rich van Konynenburg's) - article
    http://www.gordonmedical.com/unravelling-complex-chronic-illness/update-on-the-methylation-protocol

    ===
    NW Integrative Medicine
    MTHFR - article
    http://www.nwhealthcare.net/index.php?id=64

    ===
    Rawlins, Dr. Neil
    MTHFR protocol - document
    updated Jul 21, 2010: https://docs.google.com/viewer?url=http://www.rawlins.org/mthfr/MTHFR protocol.doc
    updated Nov 7, 2011: http://www.docstoc.com/docs/135451481/rawlins-mthfr-nutritional-protocol
    updated Feb 28, 2012: http://www.rawlins.org/mthfr/talk summary revised.doc

    Rawlins, Dr. Neil
    MTHFR, Sept 2011 - video
    http://www.methyl-life.com/a-doctor-explains.html
    http://www.renewashoe.com/medical/

    Rawlins, Dr. Neil
    MTHFR: Help from the Human Genome Project - document
    http://www.rawlins.org/mthfr/MTHFRdeficiency.ppt

    ===
    Roberts, Dr. James
    Methyl Cycle Nutrigenomics - article
    http://www.heartfixer.com/AMRI-Nutrigenomics.htm

    ===
    Smith, Dr. Stephen
    Mindmap of MTHFR - document
    http://www.mindmeister.com/12694596/mthfr-related-health-problems

    Smith, Dr. Stephen
    MTHFR & Fibromyalgia - video
    https://www.youtube.com/watch?v =3KylT1Muvq8 (to watch, take out the spaces in front of "com" and the "=")

    Smith, Dr. Stephen
    MTHFR Heterozygous versus Homozygous - video
    https://www.youtube. com/watch?v =tBUCeulUoe0 (to watch, take out the spaces in front of "com" and the "=")

    ===
    SNPedia
    Yasko Methylation - article
    http://www.snpedia.com/index.php/Yasko_Methylation

    ===
    Stewart, Dr. Kendal
    Seminar at Neurosensory Center of Charlotte - video (5 videos in total)
    http://www.youtube. com/watch?v =J5m2jfiSnN4 (to watch, take out the spaces in front of "com" and "=")

    ===
    van Konynenburg, Dr. Rich
    2011 presentation in Sweden, part 1 - documenthttp://iaomt.media.fnf.nu/networks/iaomt/IAOMT_talks_Rich_Van_K._2011__Part_1R.pdf

    van Konynenburg, Dr. Rich
    2011 presentation in Sweden, part 2 - document
    http://iaomt.media.fnf.nu/networks/iaomt/IAOMT_talks_Rich_Van_K._2011__Part_2.pdf

    van Konynenburg, Dr. Rich
    2011 presentation in Sweden - video
    http://iaomt.media.fnf.nu/2/skovde_2011_me_kroniskt_trotthetssyndrom/

    van Konynenburg, Dr. Rich
    Revised Simplified Methylation Protocol (August 25, 2012 Revision) - forum posting
    [This was his last version of his protocol before his untimely death.]
    http://forums.phoenixrising.me/inde...ation-protocol-august-25-2012-revision.19050/

    van Konynenburg, Dr. Rich
    Multiple links put together by Phoenixrising.me - documents
    [Note: Most of these documents are from 2008 or earlier, and some of the advice given, and the particular protocol components and steps, was later updated by Dr. van Konynenburg in other places, so read widely to make sure you know his final position on any particular topic.]
    http://phoenixrising.me/treating-cf...thylation-cycle/comment-page-1#comment-559145

    van Konynenburg, Dr. Rich
    Where are we on understanding and treating ME/CFS today? - article/discussion thread
    http://forums.phoenixrising.me/inde...nderstanding-and-treating-me-cfs-today.15509/

    van Konynenburg, Dr. Rich
    Documents by Rich Van Konynenburg: Parts 1-7
    (This list was finalized by Rich in March 2012)
    http://forums.phoenixrising.me/inde...-van-konynenburg-parts-1-7.11488/#post-198778

    van Konynenburg, Dr. Rich
    A list of methylation protocols - forum discussion
    "...[In addition to Rich's and Freddd's protocols] there are also several other methylation-type treatments in use now, and they have all helped at least some people. They include the following:
    The S. Jill James and the DAN! project protocols
    The complete Amy Yasko treatment program
    The Alan Vinitsky protocol (which uses hydroxocobalamin and high-dose folic acid)
    The Derek Enlander protocol
    The Sarah Myhill protocol
    The Martin Pall protocol (which is moving toward including liposomal hydroxocobalamin and oral 5-methyl tetrahydrofolate
    The PamLab prescription "medical foods": CerefolinNAC and Metanx
    All these protocols are aiming at boosting the activity of methionine synthase, in my opinion, and all of them are helping some people. It would be helpful if there could be a controlled clinical comparison of these treatments on well-specified ME/CFS patients, but since for the most part these are non-patentable treatments, there is not likely to be funding available for this. In the meantime, we are operating on the basis of projections from available theory, limited clinical testing, and a lot of anecdotal reporting. It does seem to be true that methylation treatment in general is growing among the complementary and alternative physicians who treat ME/CFS and Lyme disease."
    http://forums.phoenixrising.me/inde...idiots-guide-to-methylation-block-theory.9791

    ===
    Walsh, Dr. Bill
    Overmethylation and Undermethylation - videos
    (Scroll down on the following page to find them - these two videos are in the middle of his list of videos. I had problems linking to them directly here.)
    http://www.walshinstitute.org/Video.asp

    ===
    Whitehead, Thomas
    The Methylation Cycle - article
    http://www.ceu-usa.com/courses/WC001/test_drive/methylation_cycle.htm

    ===
    Woeller, Dr. Kurt
    Genetic Analysis Report based on Dr. Amy Yasko's work - document
    http://www.vsan.org/rok-az/methylation/Genetic_Analysis_Report_summary_sheet_1.pdf

    ===
    Yasko, Dr. Amy
    Autism Pathways to Recovery book - document
    http://www.holisticheal.com/media/downloads/autism-pathways-to-recovery-book.pdf

    Yasko, Dr. Amy
    Pathways book's accompanying Workbook - document
    http://www.holisticheal.com/media/downloads/autism-pathways-to-recovery-workbook.pdf

    Yasko, Dr. Amy
    Your Simplified Roadmap to Health - document
    http://www.scribd.com/doc/132017201/Dr-Amy-s-Simplified-Road-Map-to-Health

    Yasko, Dr. Amy
    17 free documents
    http://www.scribd.com/DrAmyYasko/

    Yasko, Dr. Amy
    31 videos
    http://vimeo.com/user7483551/videos

    ===

    ********************************************************************************************
    2. GENETIC TESTING RESOURCES

    23andMe
    Kit, dataset, and report, $99
    https://www.23andme.com

    Yasko, Dr. Amy
    DNA Methylation Pathway with Methylation Pathway Analysis, $495
    http://www.dramyyasko.com/our-unique-approach/why-this-test
    http://www.holisticheal.com/health-tests/nutrigenomic-testing

    *******************************************************************************************
    3. PROGRAMS THAT ANALYSE AN INDIVIDUAL'S 23andMe GENETIC DATA

    cost: free (a donation is optional)
    GeneticGenie
    by kday, member of PhoenixRising @kday
    http://geneticgenie.org/

    cost: free
    Analyze My Genes
    by Valentijn, member of PhoenixRising @Valentijn, and "jvogel72"
    http://sourceforge.net/projects/analyzemygenes/
    for more information and to give input to the developers, see the following threads:
    a. http://forums.phoenixrising.me/index.php?threads/download-for-rare-snp-analysis.24983/
    b. http://forums.phoenixrising.me/index.php?threads/creating-snp-panels-feedback-on-appearance.23555/

    cost: free
    Minor Allele Program
    by Ian Logan
    http://www.ianlogan.co.uk/23andme/23andMe_index2.htm

    cost: either free, $2, or $5, depending on the option you select
    Promethease
    by SNPedia
    http://www.snpedia.com/index.php/Promethease

    cost: $20
    Livewello
    by Dr. Kwame Iwegbue and Florence Iwegbue
    https://livewello.com/23andMe
    https://docs.google.com/file/d/0B-JQdCt-ZuqIVUpMbUtJajZiLW8/preview?pli=1

    cost: $20
    MTHFRsupport Reports
    by Sterling Hill
    http://www.mthfrsupport.com/reports-consults/

    cost: reportedly $50 (the price does not seem to be published online, but a PhoenixRising member who purchased this report said in a thread that it cost $50)
    Living Wellness Personalized Video Report
    by Thane Frederickson
    https://www.facebook.com/livingwellnesstoday/info
    Genetic Genie Methylation Analysis Demo - part 1 - video
    http://www.youtube. com/watch?v =2hZy8nr-vi8 (to watch, take out the spaces in front of "com" and "=")
    Genetic Genie Methylation Analysis Demo - part 2 - video
    http://www.youtube. com/watch?v =kBsfq2_qRqw (to watch, take out the spaces in front of "com" and "=")

    cost: free
    OpenSNP
    http://opensnp.org/
    Note: The above site publishes your data in the public domain (their FAQ page says, "The data will then be openly available for the world to see and download"). You may wish to consider the ramifications of publicly revealing your 23andMe dataset as a whole. These days, once something is online, even if you try to remove it later, there will be many copies that you won't be able to erase. If you do decide to upload your data there, it would be prudent to remove your real name from your 23andMe file, and to create a user name for that site which you don't use elsewhere and which does not contain identifying information.
    On the plus side, the site is reported by PhoenixRising members to provide users with an automated Ian Logan "Minor Allele Program" report (which otherwise is somewhat complicated and time-consuming to create on one's own).

    //////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////
  2. helen1

    helen1 Senior Member

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    B.C., Canada
    Thank you so much Blubell. Great to have these all in one place.
  3. juniemarie

    juniemarie Senior Member

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    Albuquerque
    Fantastic Thanks Bluebell You really rolled up your sleeves on this post! this kind of post It should be a sticky.......so helpful to us all and especially new folks who come with piles of questions in a daze about where to begin.
  4. nandixon

    nandixon Senior Member

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    OpenSNP is useful for a number of reasons, but one is that when you upload your 23andMe data (as a text file) to openSNP, Ian Logan's free Minor Allele Program ("rare allele program") will be run for you automatically, as opposed to having to manually input the data yourself. See Valentijn's thread here for more information:
    http://forums.phoenixrising.me/index.php?threads/rare-allele-data.23978/

    Obviously, if you have any concerns about privacy you should remove your name before uploading your data file and not use your real name when registering with openSNP. You can also always delete your uploaded file once you've obtained your rare allele report. (Note: That report will become public since Ian provides you with a publicly viewable link to see your results. Here is mine, for example: http://www.ianlogan.co.uk/23andme/open/nandixon.htm)

    I found the rare allele/SNP results to be much more useful than, for example, my Yasko methylation results. Most of the Yasko SNPs, singularly or in combination, are rather common in the general population.

    On the other hand, identifying one's rare allele/SNPs, which are likely to be much less common in the healthy population, and therefore more likely to be problematic than the methylation SNPs, can be very helpful.

    I've only just begun to research all of mine, but I've already found that addressing a rare homozygous peroxisomal defect I have - using forskolin to raise cyclic AMP levels - has greatly increased my energy levels, and I'm in the process of trying to address an even rarer heterozygous chloride channel defect to possibly additionally help with muscle strength.

    I likely would have never discovered either of these SNPs without the rare allele program. Certainly nether the Mayo Clinic, Johns Hopkins, and too many other facilities to mention, found these issues with any of the testing they did.

    In addition to openSNP and the rare allele program, Promethease may also be helpful as well. Good luck!
    helen1, Valentijn and Little Bluestem like this.
  5. juniemarie

    juniemarie Senior Member

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    Albuquerque
    Bluebell Do you happen to know which of the Freds Protocol links has the latest revision? I know the supplements and the brands just want to make sure I do them in the correct order.......been using the google search here at PR but still not found the latest........
  6. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    Here is, to my knowledge, the most recent consolidated info:
    http://forums.phoenixrising.me/inde...t-hole-insufficiency.22614/page-2#post-345537

    The long version, which is very dense, and may not state precisely doses, is:
    THE COMPLETE METHYLATION REVIEW Fredd Feb 2013
    http://forums.phoenixrising.me/index.php?threads/the-stages-of-methylation-and-healing.21725/
  7. Bluebell

    Bluebell Senior Member

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    I am afraid I do not know. It would be great to have a one-page summary of what the protocol is, at the present time. Just the facts on: what, when, how. :)
  8. juniemarie

    juniemarie Senior Member

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    Albuquerque
    I agree Sifting through all those long discussions about his protocol is like looking for something in a bucket of worms. Makes your head swim. Why cant we have a sticky with just the what, when and how......one where no one post anything else like added discussion or whatever. If I find one I will send the link to you to add to your impressive collection..........I swear that was a brilliant idea Bluebell as its so very difficult when you have brain fog issues to get to the heart of the matter
  9. Bluebell

    Bluebell Senior Member

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    I'm so glad it is helpful. :)

    My list is pretty long now and I know that there's "everything but the kitchen sink" in there, but I like to source information widely and reach across fields, professions, and communities that are (understandably) focussed on one illness, to see what others' perspectives are. One never knows if a little tidbit of information from an obscure reference might provide someone with a missing piece of their puzzle!

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