The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
Discuss the article on the Forums.

Ubiquinol-10 improves autonomic nervous function and cognitive function in CFS

Discussion in 'Latest ME/CFS Research' started by AndyPR, May 1, 2016.

  1. AndyPR

    AndyPR Senior Member

    http://www.ncbi.nlm.nih.gov/pubmed/27125909
     
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  2. charles shepherd

    charles shepherd Senior Member

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    MEA comment:

    Although this supplement is quite often used by people with ME/CFS, there has been no sound evidence from a clinical trial till now to indicate that it could be a safe and effective form of treatment for ME/CFS

    General information on co-enzyme Q10:
    http://www.medicinenet.com/coenzyme_q10_ubiquinone_ubidecarenone-oral/article.htm

    MEA information on co-enzyme Q10 from an MEE Question and Answer below

    We also have an MEA information leaflet summarising the evidence for all the 'muscle energy supplements' >>

    MEA literature order form:

    http://www.meassociation.org.uk/wp-content/uploads/MEA-Order-Form-Feb-2016.pdf

    QUESTION: Coenzyme Q10 – does it work?


    My nutritionist has advised me to start taking a supplement called coenzyme Q10 (CoQ10) which, she says, will boost my energy levels. So what is CoQ10 and is this claim correct? Are there any side-effects? And can I take it with prescription only medicines?


    ANSWER


    Coenzyme Q10 (CoQ10), which is also known as ubiquinone, is often referred to as a vitamin. However, this isn't strictly true as it is made in the liver from an amino acid called tyrosine. CoQ10 is also present in a wide variety of foods. So deficiency can occur as a result of reduced dietary intake, decreased production, or increased usage - or a combination of all three.


    CoQ10 is known as a coenzyme because it helps other enzymes in the body to carry out their normal functions. In relation to muscle fatigue, it is involved in energy producing chemical pathways inside the mitochondria - parts of the cell where energy in the form of a chemical called ATP is produced. It also has antioxidant activity. So there are clearly some theoretical reasons why CoQ10 might be helpful in ME/CFS.


    However, despite all the claims being made for CoQ10, there is very little scientific evidence linking deficiency with disease. Neither is there much evidence of benefit in diseases where it is sometimes recommended such as heart failure, mitochondrial muscle diseases, and Parkinson's disease (where decreased levels have been found in the spinal fluid). The same situation applies to ME/CFS.


    As far as side effects are concerned, CoQ10 is normally well tolerated with no serious side-effects. But it has not been properly assessed in pregnancy.


    One important note of caution relates to its use with statins - prescription only drugs used for lowering blood cholesterol levels. Statins can lower the levels of CoQ10, and it has been suggested that this could make people more liable to develop statin-induced myopathy (muscle damage). This is a well recognised side-effect of statins, and is something that is occasionally reported by people with ME/CFS. So there may be a case for taking CoQ10 if you have ME/CFS and are also taking a statin. It has also been reported that CoQ10 can interfere with anticoagulants (blood thinning drugs such as warfarin) at high doses.


    Overall, CoQ10 is a supplement that may be worth a try - bearing in mind that reports of benefit are speculative rather than scientifically proven.


    [​IMG]

    Dr Charles Shepherd
    Hon Medical Adviser, MEA
     
    Last edited: May 1, 2016
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  3. Marky90

    Marky90 Science breeds knowledge, opinion breeds ignorance

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    Any objective tests? And what is "effective"?

    Don`t have paper acess..
     
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  4. charles shepherd

    charles shepherd Senior Member

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    Yes, I would like to know as well. Don't yet have the full paper……..
     
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  5. aimossy

    aimossy Senior Member

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    I find this interesting because I tried supplementing with this and did not tolerate it well at all. They state in the abstract:

    "The RCT results suggest that supplementation with ubiquinol-10 for 12 weeks is effective for improving several CFS symptoms."
     
  6. Hip

    Hip Senior Member

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    I'd be interested in knowing which particular ME/CFS symptoms Q10 improves (in addition to cognition and autonomic function — I am sure there must be other symptoms which were imporved). The full paper does not yet seem to be available on Sci-Hub (the main Sci-Hub website is currently down, but they can be reached on http://sci-hub.cc).

    There was a small previous study that looked at Q10 for ME/CFS patients.
     
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  7. deleder2k

    deleder2k Senior Member

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  8. Hip

    Hip Senior Member

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    There are also some very good deals on bulk Q10 powder on aliexpress.com (which is a sort of Chinese eBay). Typically around $200 for 500 grams of 98% Q10 powder.


    For comparison purposes, Q10 ubiquinone powder bought at purebulk.com costs around $29 for 25 grams, and $202 for 250 grams.
     
    Last edited: Oct 29, 2016
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  9. Hip

    Hip Senior Member

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  10. deleder2k

    deleder2k Senior Member

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    How safe is it to buy supplements from China..?
     
  11. Hip

    Hip Senior Member

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    I have read that some Chinese herbal supplements can have high levels of mercury, but I don't think that applies to pharmaceutically-produced products, such as Q10.
     
  12. deleder2k

    deleder2k Senior Member

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    Okay, thanks. I think I'll stick with iHerb's 87% price cut ;)
     
  13. Hip

    Hip Senior Member

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    I am currently using a batch of Chinese Q10 powder bought on Aliexpress, and it has the nicest, smoothest taste out of all the Q10 powders that I have tried over the years, including Q10 powers I bought from people such as Now Foods supplements. So from the taste it seems good.
     
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  14. greeneagledown

    greeneagledown Senior Member

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    The abstract is pretty thin. If anyone has access to the full paper, I'd love to know a) what kind of p-values we're talking about here, and b) the practical magnitude of the improvement.
     
  15. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    Is Ubiquinol-10 any different than the ubiquinol currently available in supplements?
     
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  16. Mij

    Mij Senior Member

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  17. Dolphin

    Dolphin Senior Member

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    I have heard it is available there now.
     
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  18. Dolphin

    Dolphin Senior Member

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    Fukuda 2016 table 3.png

    The p-values are close to .05 but at the same time the sample size in the study is quite small so harder to get statistically significant results. It's a pity they don't give all the data i.e. for the results that were not statistically significant.
     
    Last edited: Aug 6, 2016
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  19. Dolphin

    Dolphin Senior Member

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  20. Dolphin

    Dolphin Senior Member

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