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How much CoQ10 do you take?

Discussion in 'General Treatment' started by SOC, Mar 22, 2014.

  1. SOC

    SOC Moderator and Senior Member

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    I've been taking 200 mg for quite some time to only small effect. Recently I tried increasing to 800 mg and have noticed an increase in my PEM threshold, although with other things going on, I'm not certain the change in CoQ10 dosage is the reason.

    I've read people taking as much as 1200-1500mg daily and am debating increasing my dosage again as an experiment.

    What dosage have you found to be effective and also what problems have you had with CoQ10?
    heapsreal likes this.
  2. tdog333

    tdog333 Senior Member

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    Do you have candida?
  3. minkeygirl

    minkeygirl Senior Member

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    One of my cousin's 2 children had Huntington's Disease and she used very high doses with them. I think they were taking 1200 mgs. I don't remember if there were any problems with them, only plusses.
  4. maryb

    maryb iherb code TAK122

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    I can't tolerate it at present, I was able to take quite a high dose but now for some reason my body rejects it totally.
  5. SOC

    SOC Moderator and Senior Member

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    No
  6. tdog333

    tdog333 Senior Member

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    I was wondering because candida competes and uses up your CoQ10
    http://www.ncbi.nlm.nih.gov/pubmed/12606233

    some more:



    Some people do a "parasite cleanse" using 3000 MG of CoQ10 taken once. Never heard of any bad effects so it seems pretty safe.
    Last edited: Mar 22, 2014
    SOC likes this.
  7. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I take 100mg twice a day.
    How long did it take to see an effect from the high dose?
  8. SOC

    SOC Moderator and Senior Member

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    Assuming it was the CoQ10 (which I can't be sure) I saw an effect within 2 weeks, maybe less.
    heapsreal likes this.
  9. Hip

    Hip Senior Member

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    I have also noticed a PEM reducing effect of Q10, and I often take Q10 for this reason.

    I find that you do not have to take Q10 daily to get this PEM-busting effect: you just need to take Q10 an hour before the exerting activity that you are about to partake in, and this I find prevents a lot of the PEM that you would normally experience when the activity is over. I use a dose of 400 mg of Q10 for this anti-PEM purpose.

    I get ME/CFS PEM mainly from mental exertion (rarely from physical exertion), and for me, 3 or 4 hours of socializing with friends causes a lot of PEM the following day or two. However, if I take 400 mg of Q10 just before I begin this 3 or 4 hours of social activity, my PEM is noticeably reduced. Note that Q10 is most cheaply purchased in bulk powder form.


    I also found two other medications with anti-PEM effects (ketoconazole 200 mg, and erythromycin 800 mg) but I am less sure about these, and I have to test them further before I can say for definite that they help minimize PEM.


    PEM-busting supplements or drugs that you can take just before an exerting activity, so as to lower or prevent PEM, are really an unexplored area on this forum. I suspect there may be quite a few supplements and medications with anti-PEM effects, but nobody has properly noticed them.

    In order to discover and identify any PEM-busting supplements, you would need to test them using an exerting activity you do on a regular basis, like say doing your regular weekend shopping (so that you know from past experience just how much PEM will arise from the activity), and then take a supplement like Q10 an hour before starting this regular activity, and see if you get less PEM than normal.
    Last edited: Mar 22, 2014
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  10. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    SO it would seem the whole PEM thing is more to do with mitochondria then infections/immune system??
  11. SOC

    SOC Moderator and Senior Member

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    My guess is it's both. Why, I have no idea. :)
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  12. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Gut seems to be involved, but that could be the immune connection too.

    Sushi
    SOC likes this.
  13. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    i cant say i notice much with q10 but will try higher doses. but i am noticing effects with acetyl carnitine
  14. SOC

    SOC Moderator and Senior Member

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    Isn't this the way with ME/CFS? I don't see any effect with acetyl carnitine. How much alcar do you take?
  15. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    using 500mg mostly, recently up to 1000mg.
    SOC likes this.
  16. Hip

    Hip Senior Member

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    It might perhaps be more to do with cytokines: IL-6 has been theoretically linked to PEM; see the following except from an article by Cort:
    Now it just so happens that Q10 inhibits IL-6, or at least does in the context of coronary artery disease.

    Furthermore, macrolide antibiotics (like azithromycin and erythromycin) inhibit IL-6 (ref: here), and I found that erythromycin 800 mg seemed to have an anti-PEM effect, though I need to confirm this with more testing.

    If IL-6 is the PEM mechanism, then perhaps other IL-6 inhibitors, taken just before the period of exertion, will also offer anti-PEM benefits.
    Last edited: Mar 22, 2014
  17. lnester7

    lnester7 Seven

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    @SOC I did my best with CO10 at 800mg a day, You can actually go up a lot. AND IT WORKS the problem is COST COST COST, the only reason I stooped the high doses is because It was soooo expensive.

    Do not take it all at once, if you load throughout the day you will have better results. I have done as much as 400 w Breakfas, 400mg more for lunch. I do not take after 2pm or 4pm on days I will have long nights.

    I might try this again and go up to 400mg 3 times a day.
  18. SOC

    SOC Moderator and Senior Member

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    Thanks. :) Yes, cost is a big issue, so I'm trying to optimize. I don't want to take more than is effective for me.

    Right now I'm taking 600mg at breakfast and 200 mg at lunch. Maybe I'll try 600mg at breakfast and lunch. I do run out of energy by dinnertime even when I'm pacing carefully and resting during the day, but I'm concerned about sleep problems, so I don't really want to take CoQ10 later in the day.

    I read that CoQ10 level peaks about 5-6 hrs after taking it and the half-life is about 36 hours, so it seems that it shouldn't be necessary to dose later than lunchtime.
    lnester7 likes this.
  19. lnester7

    lnester7 Seven

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    Soc try 600, 400, 200 4pm. I have done 800 am 800 12pm and I was literally SOOOO hyper. so I think my number is in the 400s. I am starting to increase soon to optimal numbers, when I see it stop will just stay at that dose. I also decided to keep on pedyalite, I stopped because of price but I feel so much better OI wise if I take one a day. So back to the expensive that work routine (sigh)
  20. Calathea

    Calathea Darkness therapy

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    Could you make your own electrolyte drinks? Much cheaper!

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