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Is Folate inhibiting Thiamine (B-1) ?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by dannybex, May 25, 2013.

  1. dannybex

    dannybex Senior Member

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    I wasn't sure where to post this, but figured since many w/ME/CFS were or are using considerable amounts of folate with regards to methylation protocols, this might be something worth considering...

    I found this study on another forum. It's not a study of ME/CFS patients, but rather patients with diabetic kidney disease. Still, the part that caught my eye was this:

    "In addition to facilitating transport of folate, RFC-1 is also a transporter of thiamine monophosphate (TMP) and thiamine pyrophosphate (TPP)."

    http://www.medscape.com/viewarticle/731177http://www.medscape.com/viewarticle/731177

    I don't have a subscription to Medscape, but here's part of the study that was quoted on the other forum:"A further factor underlying the association of high-dose vitamin B6, B9 and B12 supplements and metabolic dysfunction in diabetic nephropathy could be the effect of high-dose folic acid on metabolite transport via the folate transporter 1 (RFC-1). In addition to facilitating transport of folate, RFC-1 is also a transporter of thiamine monophosphate (TMP) and thiamine pyrophosphate (TPP).[8] Diabetic nephropathy occurs within a background of thiamine (vitamin B1) deficiency owing to impaired renal reuptake of thiamine. Plasma thiamine concentrations were inversely linked to plasma soluble vascular cell adhesion protein 1 (sVCAM-1)—a risk marker of cardiovascular disease.[9] Folate binds to and is transported into cells by the RFC-1 transporter.[8] High-dose folic acid supplementation might exacerbate thiamine deficiency at susceptible sites, such as the kidney and vascular cells in diabetic nephropathy, by competing with TMP and TPP and impairing their uptake into tissues, thereby inhibiting sharing of thiamine metabolites between tissues rich in thiamine and those deficient in it."
    So, I guess I'm wondering if perhaps high-dose folate (even if it's not 'folic acid') might be interfering with and/or creating a thiamine deficiency, the symptoms of which can almost mimic those of ME/CFS.

    Severe thiamine deficiency is known as beriberi, which translated means, "I can't, I can't."

    ???
  2. Lotus97

    Lotus97 Senior Member

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    What if you take less folate, but more B2/R5P (which would increase MTHFR so less folate would be needed)? Would that still cause the same problem? And what about just taking extra B1?
    dannybex likes this.
  3. Victronix

    Victronix Senior Member

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    Helen and dannybex like this.
  4. adreno

    adreno 3% neanderthal

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    Tundras of Europa
    I'm guessing you could just take the two at different times. Interesting, though.
  5. Asklipia

    Asklipia Senior Member

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    About thiamine, have you read this : http://fr.scribd.com/doc/74090699/Astrophysiology-and-Yeast

    especially p.42 :
    Acetaldehyde stemming from yeast is a thiamine antagonist. It combines irreversibly with thiamine to form 2,3-butanediol, a stable adduct, that is excreted in the urine. The thiamine molecules thus imprisoned are no longer available for either aspect of the chi cycle. Thiamine is required for the liver energy requirements during the aldehyde dehydrogenase oxidation of acetaldehyde and for neutrophils that attempt to surround and destroy budding yeast as it shifts into its hyphal form. Responding to the metabolic impact of yeast in the system has increased the demand upon thiamine reserves already serving the energy requirements of every other active cell in the body's conglomeration of organs and tissues.
    When all of these concurrent demands reach a critical threshold and the normal background chi pressure that keeps the body's chi spring wound up creates a sudden shift of thiamine out of the bloodstream, then normal chi pressure becomes excessive chi stress and body processes start to fail. The symptom first experienced might be a sudden headache, hot flash, night sweat, panic attack, fit of rage, dizzy spell, nausea, spike in blood pressure, or enervating fatigue that continues to worsen until the condition becomes chronic and internal organs begin to fail. When there is an overall insufficiency of thiamine in the system, so that both blood stream and chi field requirements cannot be adequately met, the body has slipped into a state of sub-clinical beri-beri, the thiamine deficiency disease.

    and p. 46 on how to do thiamine loading.
    dannybex likes this.
  6. Lotus97

    Lotus97 Senior Member

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    I just take relatively high doses of most vitamins and minerals and just let my body sort things out. I'm not necessarily recommending that strategy, but that's my gameplan at the moment:cool: Maybe one day I'll be able to afford to get all my minerals and vitamins tested to know where my imbalances are. One can dream.
    dannybex likes this.
  7. dannybex

    dannybex Senior Member

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    Thanks for all the replies...and thanks for posting the full study Victronix. Who knows...the fact that they used 'folic acid' may make some difference in the results, but for now I'm going to assume that overall, all folates would use the same receptor. ???

    Lotus, that's a possibility re the b2/r5p. I'm cutting back on folate for now, as I've been supplementing with methylfolate and folinic, and while they help in some ways (definitely can sleep better with the folinic). But I have many of the unique symptoms of thiamine deficiency, like loss of appetite, delayed stomach emptying (for YEARS), and the most telling of all, the strange combination of considerable muscle wasting in my feet, yet with some edema as well. Skinny as hell, but still edemic. They're also very painful...(lactic acid?)...can hardly walk the last 2 years (got slowly worse while increasing folate and methyl-b12, but also while ignoring the krebs cycle, which needs b1, b2, b3, b5 and assorted other compounds).

    Thanks Asklipia for the post about acetylaldehyde and thiamine. I've been reading about a lot of things that inhibit/block/interfere with thiamine, but that one specifically wasn't on my radar.

    There are indeed quite a few anti-thiamine (thiaminase) compounds...from my googling, here's at least some more to consider:

    Horsetail (silica)
    Red Fern
    Blueberries
    Red Chicory
    Red Currants
    Red Beets
    Brussel sprouts
    Red cabbage
    Molds like aspergillus, fusarium moniliform, fusarium proliferatum (the latter two 'produce a powerful thiaminase'), and all three can be found in wheat, corn and their byproducts.

    And this quote that thiaminase enzymes are most often 'found in colored plants'...'the anti-thiamine activity is bound to phenolic compounds'. So perhaps that ties in with the salicylate/phenol intolerance that myself and others have experienced for years.

    ???
  8. dannybex

    dannybex Senior Member

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  9. Little Bluestem

    Little Bluestem Senescent on the Illinois prairie, USA

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    Yet we are told that ‘colored plants’ such as blueberries, red beets, Brussel sprouts, and red cabbage are healthful. Maybe we just need to take/eat more thiamine?
  10. dannybex

    dannybex Senior Member

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    I know. It's very confusing and complicated...lots of conflicting advice out there. But I've too been wondering if perhaps a salicylate/phenol intolerance may develop due to an overall depletion of thiamine (and perhaps other b's). In fact, a woman posted the other day on another forum that her son's salicylate intolerance resolved after they increased his thiamine.

    Here's a book that kind of aptly describes the salicylate intolerance problem -- the title says it all:

    http://www.amazon.com/Salicylate-Intolerance-Healthier-Revised-Edition/dp/0615317979
  11. Sparrowhawk

    Sparrowhawk Senior Member

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    Oh lordy, and I've been eating radicchio every day for the past five months... I assume that's in the same boat with red cabbage.

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