A New Decade of ME Research: The 11th Invest in ME International ME Conference 2016
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Food sensitivities and PST

Discussion in 'Addressing Biotoxin, Chemical & Food Sensitivities' started by Gondwanaland, Sep 29, 2014.

  1. Gondwanaland

    Gondwanaland Senior Member

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    I recently experienced salicylate sensitivities and recovered my ability to detox phenols by supplementing magnesium oxide and Saccharomyces boulardii.

    These were the pieces of my puzzle:
    • urea and uric acid above range in blood
    • urine pH low (4.5 - 5.0)
    • magnesium in urine very low below range
    I would like to paste here the references that helped me most:

    This reference is also useful because at the same time I experienced intermittent goiter:

    You can read all about magnesium here, here and here. Especially here, including warnings and toxicity.
    Free download booklet: the 2nd chapter includes a list of magnesium depleting drugs and the last chapter mentions allergies related to magnesium deficiency.
    Mercola recently stated that Clostridia helps prevent sensitization to food allergens. In this case beware of overdoing S. boulardii, which is recommended to fight Clostridia strains.

    Since I don't know my SNPs, I am navigating through symptoms.

    I hope this info can help someone.

    izzy
     
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  2. Gondwanaland

    Gondwanaland Senior Member

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    Just found out that I have a series of impairments with the PST enzymes. My husband, OTOH is all clear for this gene.
    SULT1A1 28617057 rs1042157 A or G AG
    SULT1A1 28617448 rs35728980 G or T GT
    SULT1A1 28617514 i6018900 C or T CT
    SULT1A1 28617574 rs4149394 C or T CT
    SULT1A1 28617595 rs4149393 A or G no call
    SULT1A1 28618933 rs2925628 C or T CT
    SULT1A1 28632021 rs2411453 G or T GT

    From here on DH also has some +/- and no calls, not the same ones as mine
    SULT1A2 28603655 rs1059491 G or T GT

    SULT1B1 70592790 rs2292092 G or T GT
    SULT1B1 70599073 rs1847366 C or T CT
    SULT1B1 70611119 rs1604741 A or G AG
    SULT1B1 70612712 rs11727948 A or G AG
    SULT1B1 70614259 rs1604747 A or G AG
    SULT1B1 70616322 rs1354360 A or G AG

    SULT1C2 108912150 rs12990757 A or G AG
    SULT1C2 108912673 rs13410305 A or C AC
    SULT1C2 108916044 rs4149423 A or G AG
    SULT1C2 108925572 rs11689841 A or G AG
    SULT1C2 108926033 rs17821546 A or G AG

    SULT1E1 70709023 rs1238574 C or T no call
    SULT1E1 70718282 rs3775775 A or G AG
    SULT1E1 70719238 rs3775774 C or T CT
    SULT1E1 70725821 rs3736599 C or T CT

    SULT2A1 48377519 rs4149452 C or T CT

    SULT2B1 49061724 rs3848542 A or G AG
    SULT2B1 49070392 rs2665601 A or G AG
    SULT2B1 49071756 rs2544800 A or G AG
    SULT2B1 49077667 rs3760808 C or T CT
    SULT2B1 49079246 rs2544794 C or T CT
    SULT2B1 49098750 rs12460535 A or G AG
    SULT2B1 49102399 rs1132054 C or T CT

    SULT4A1 44225888 rs2285158 A or G AG
    SULT4A1 44236864 rs4149442 C or T CT
    SULT4A1 44248601 rs2285161 C or T CT
    SULT4A1 44250570 rs138097 A or G AG
    SULT4A1 44251326 rs2285168 A or G AG
    SULT4A1 44255332 rs739230 C or T CT
    SULT4A1 44255832 rs138105 A or G AG
     
    Last edited: Dec 1, 2014
  3. melamine

    melamine Senior Member

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    Upstate NY
    Good sleuthing, Gondwanaland! :thumbsup:
     
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  4. Gondwanaland

    Gondwanaland Senior Member

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  5. Gondwanaland

    Gondwanaland Senior Member

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    Looking further into glucuronidation:
    Glucuronidation.png
    Detoxification of Phenols by Sulphate Conjugation: An Alternative to Glucuronidation in an Enzymatic Liver Support System (no full access)
    Liver1981-1.jpg
    Liver1981-2.jpg

    Next step: look up the UGT SNPs on 23andMe.
     

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