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Accutane, Methylation Block and Glycine N-Methyltransferase

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by droit, Oct 23, 2013.

  1. droit

    droit

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    Dr. Van Konynenburg had previous post a few times on a well established pattern of Accutane causing a hyperactive Glycine N-Methyltransferase (1-6).

    http://forums.phoenixrising.me/inde...ed-depression-isotretinoin.12117/#post-206039
    http://forums.phoenixrising.me/inde...h-can-you-pitch-in-on-this.16078/#post-257280

    As Rich explains Glycine N-Methyltransferase which regulates the ratio of SAMe to SAH. If hyperactive in the way that the cited research says, SAMe is quickly converted to SAH, losing its methyl group to glycine.

    I would agree that it would be tough to overcome that force to rebuild the methylation cycle without the right intervention.

    Rich said that for some it was persistently in a locked increased activity/expression even after stopping Accutane. And noted that this enzyme is allosterically inhibited by Methyl-folate, as is documented in the literature (5-6).

    I wonder if anyone on the board tried higher doses of methyl-folate this and what doses they tried? What was the outcome?

    1. "All-trans-Retinoic Acid Rapidly Induces Glycine N-methyltransferase in a Dose-Dependent Manner and Reduces Circulating Methionine and Homocysteine Levels in Rats," http://nutrition.highwire.org/content/133/12/4090.full

    2. "Retinoic Acid and Glucocorticoid Treatment Induce Hepatic Glycine N-Methyltransferase and Lower Plasma Homocysteine Concentrations in Rats and Rat Hepatoma Cells," http://jn.nutrition.org/content/133/11/3392.full

    3. "Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific," http://www.ncbi.nlm.nih.gov/pubmed/12054489

    4. "Decreased plasma folate concentration in young and elderly healthy subjects after a short-term supplementation with isotretinoin," http://onlinelibrary.wiley.com/doi/...sCustomisedMessage=&userIsAuthenticated=false

    5. "Inhibition of glycine N-methyltransferase by folate derivatives: implications for regulation of methyl group metabolism," http://www.sciencedirect.com/science/article/pii/S0006291X85800061

    6. "Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural ligand," http://www.jbc.org/content/264/16/9638.full.pdf
    Laurel6123 likes this.
  2. GenDylan

    GenDylan

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    funny that this thread pops up now.. i am about to go on All Trans Retenioc Acid (like Accutane) so i can increase the GNMT enzyme.. why? because i took Methionine, and it raised my SAM - SAM is an allosteric inhibitor to MTHFR - im having severe histamine reactions now due to the SAM induced lack of Folate.
  3. Ivmi

    Ivmi

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    I took accutane in 2009. for 9 days only...and all those years later I'm experiencing longl list of symptoms: hair loss, impared wound healing, skin thinning, dry eyes... Month ago I did the liver cleanse by Hulda Clark, and new symptoms appeared that freaked me out: my armpit got swollen, and some wierd feeling on my neck on the same side appeared...few weeks later ultrasound found that i have lymph node swelling. I panicked! I wan't to forget about accutane and its side effects...could supplements like homocysteX Plus from Seeking health, help? What about Rick Simpson oil? Some guys were writting that it has help them... Please give me some answers :(
  4. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Concord, NH
    I have taken accutane also in the past, I see that some lawyers try to sue them for something, wonder what, if anything, accutance had to do with my illness?

    GG
  5. Ivmi

    Ivmi

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    GG what is your illness? What are you dealing with? I'm not interested in suing anyone I just want to get better. If anyone succeded with methylation or something...please tell me...
  6. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Concord, NH
    Been diagnosed with CFS and Fibromyalgia, and also Myofascial Pain Syndrome. So dealing with pain all the time, not as bad as it used to be, but on a daily basis. Fatigue from the most trivial things, brain fog, TMJ, sore muscles and joints and perhaps IBS?

    GG
  7. zzz0r

    zzz0r Senior Member

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    Very interesting thread. I was receiving accutane for 2 years. The symptoms of accutane treatment are very similar to folate deffeciency symptoms

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