Rich, I was wondering if you wouldn't mind giving me some input in whats going on with me. I know you have your head around this stuff much better than I do. If you can see any patterns or avenues for more checking for me, i'd much appreciate it. Vital precursors to CFS Roaccutane for 6 months+, this dried me out and started giving me sensitivities. Big doses of vitamin a. GF got kissed by a stripper on a cruise, i kissed her then got progressively worse when most colds/flus dont hit me. Then had wisdom teeth taking out soon after. Shock/Freeze moment where my mouth went dry and i couldnt say or process anything - with then Gf when she wanted to break up with me. Saw neck cracking chiropractors for a few months. BAD BAD BAD. I have come off Effexor completely after 4 months on these supplements. And feel really good. Supplements I benefit from: SAM-e: As soon as i started taking i had massive energy fix, which has lasted - 400mgs a day or 1 tab each of TMG 500mgs & l-methionine 500mgs. Zinc: Solgar zinc complex 15 mg zinc, molybdenum and manganese twice a day. This complex just feels so good for me. Improves my warmth/skin color. P5P/B6 - 50mgs twice a day. I can feel quite heady with this, therefore i've been occasionally been putting the B2 100mgs in every couple of days. My dream recall and visualising behind closed eyes has improved 40% from these. Evening Primrose Oil 1000 mgs/day - Tried plenty of other fish oils with no long term benefits, this is making me feel hydrated. Potassium/Magnesium - potassium phosphate dibasic 33mgs /magnesium phosphate 65mgs - Magnesium on its on seemed to give no lasting help. This together has been amazing for feeling better. It seems like i only benefit from small doses every now and then though. Supplements i have had troubles with: B12/Folic Acid (tried 3 different types of b12 you and freddd suggested and 2 methylfolates) - these on their own or together. While taking this 6 months ago, after two months i started feeling more dehydrated, getting alot of cold sores and mouth aches. B-Right - Felt good for a few days then it started making me feel sick. Current improvements from supplementation: Energy is about a 8-9/10. (may settle lower after a month off effexor), mood is now 8/10. - six months ago energy was a 4, mood was a 5. Limited PEM crashes instead of all the time. Improvements to go: Less muscle pain/exhaustion/fatigue and more muscle endurance/strength. -- might manganese be indicated here? My muscle energy would be at about a 3/10. Sex issues. Main Food Cravings: Chocolate Calcium - Yoghurts, icecream, milkshakes. Food sensitivities: Fructose Corn Parsley MSG Vanillin flavoring Goats milk Rye Tense body areas: Right side of body is alot more stressed/problematic/disocciated. Top few vertebrae of neck are collapsed. Base of neck pain. Tension stuck right behind the heart point. Kidney/liver area tension. Calves tight. Numbness/tingling to pinkies on hands. Muscle strength/endurance sucks Past Important Notes Mother had bipolar and was depressed majority of my life, classic helicopter mother. Had cellulitis when i was 7, if i hadnt moved hospitals i would have probably died. Bones are very strong, muscles have always been overly tight/tense. School/life was too fast and i never felt like i had enough time to process. Thanks for reading this. If anyone else wants to comment, please feel free.