My sleep doctor has recently suggested that I might be able to trial the deep sleep enhancer Xyrem. Unfortunately, in order to qualify to take the drug I have to complete a punishing (and expensive) night + daytime sleep study, which I'm very worried will result in a serious crash. I've explored pretty much every other sleep drug, as well as the usual behavioural modifications, and while my sleep is not as bad as it used to be, I had pretty bad alpha intrusion on my previous sleep study and I still notice a fairly big boost on days that I sleep particularly 'well' (which is rare). My main symptom is severe mental PEM (e.g. no TV in the evening and only talking for an hour after dark) which deteriorates over the course of the day, but I also have POTS and most of the usual ME symptoms (flu-like, GI, nervous system stuff). Has anyone here who has primary ME/CFS taken Xyrem? If it wasn't for the the sleep study I would definitely try the drug, but it could be weeks or months before I recover and wanted to know if anyone had experienced improvements before I sign up for the study.