I'm getting very interested in genetic research, and really appreciate your comments and insights. Unfortunately I know very little about this subject. Could you do me a favor and include the SNPs when you mention a polymorphism? I don't know which SNPs to look for. Are you talking about these:
http://snpedia.com/index.php/Rs1799752
Those are not genotyped on my 23andme profile.
"Those are not genotyped on my 23andme profile"
I know, which is one reason its impossible to just use the 23&me and correlate them with Yasko's tests, plus they look at the other side of the DNA strand or something so that their positives are her negatives and vice versa but it doesn't always pan out like this so you can't even cross reference them that way! What a nightmare! My doctor is actually quite brilliant and couldn't figure it out after months of research so I didn't feel so bad when I failed at it too. But I know she'd love for someone else to do it since she wants a cheaper way to test her patients so she can spend more money treating them then testing them. I agree with that theory for sure! Plus, I'd know if I have the ACE, ACAT, SHMT, etc.
I think that number would be on that cheatsheet list that I posted before but put below again. I never remember things like those numbers and when we get our Yasko results, my kid's are all listed under the simpler ones (MTHFR, ACE, NOS) and I'd have to research each one before I listed them for you. I just wrote down simple terms alongside each one as I learned them so have things like:
MTHFR A1298C AKA Motherf*%@er gene, doesn't convert SAM to SAMe properly and causes BH4 to drop so clean up in the urea cycle is down and poor communication in the system without enough dopamine, serotonin, & norepi
ACE AKA Anxiety and adrenal crisis/response with this as well as high cortisol and adrenal fatigue, poor memory (esp for learning), and head rush central.
That sort of thing sticks in my head whereas rs 12985 doesn't at all. I don't remember if my doctor lists those or not either now that I think of it but she does list the major issues with each one so you might want to check her site out again too.
Angela
Gene Yasko
Name Yasko
normal 23andMe
Name 23andMe
normal
COMT V158M G(-) rs4680
G (plus)
COMT H62H C(-) rs4633
C (plus)
COMT 61 G(-) rs769224
G (plus)
VDR Taq T(+) (rs731236)
VDR Fok rs10735810 ?
MAO-A R297R G(-) T(+) rs6323
G (plus)
ACAT 1-02 A(+) N/A
ACE Del16 I(-) rs1799752
I (plus)
MTHFR C677T C(-) T(+) rs1801133
G (minus)
MTHFR 3 C(-) N/A
MTHFR A1298C A(-) rs1801131
T (minus)
MTR A2756G A(-) rs1805087
A (plus)
MTRR A66G A(-) rs1801394
A (plus)
MTRR H595Y C(-) rs10380
C (plus)
MTRR K350A A(-) rs162036?
A (plus)
MTRR R415T C(-) rs2287780?
C (plus)
MTRR S257T T(-) (rs2303080) ?
MTRR 11 G(-) N/A
BHMT 1 (-) rs492842? ?
(minus)
BHMT 2 C(-) rs6894156?
C (plus)
BHMT 4 (-) rs6875201 or
rs379754 (plus)
BHMT 8 T(+) rs3797546 or
rs567754
(plus)
(plus)
AHCY 1 A(-) N/A
AHCY 2 T(-) rs1205357
(plus)
AHCY 19 A(-) N/A
CBS C699T C(-) rs234706
(plus)
CBS A360A C(-) T(+) (rs1801181)
SUOX S370S (-) N/A
SHMT C1420T G(-) (rs1979277) ?
NOS D298E (-) rs1799983 ?
(plus)