- Messages
- 19
Hello everyone ... I ran my 23andme results through Genetic Genie at the end of the summer after I started some supplementation a few months earlier. I also didn't pay enough attention to my results, missing the possible importance of addressing my CBS mutation first :/
Methylation:
Heterozygous mutations (+/-)
Homozygous mutations (+/+)
*GSTT1 present
I also looked up SUOX on my 23andme and came up with CT for SUOX (rs705703) and ACE (rs4343) as AG. I'm assuming that means I'm heterozygous for both?
I had bloodwork done in early August and late October.
Vitamin D: 68 (Aug) and 38.3 (Oct).
- supplemented 2000 IU the entire time, only difference -- lost an hour of being out in the sun daily with the colder weather
B-12: 630 (Aug) and 1878 (Oct). Three-fold jump?! In September I switched to Jarrow methyl B-12 5000mg and 800 Solgar folate. Frustration level plummeted, anxiety went sky high so I cut the dosage in half and seem to tolerate it. It makes me wonder if the B12 is that high because it's going nowhere ...
In August they also ran the following:
Folate RBC
- hemocrit: 37.0
- rbc folate: 698
I also had a comprehensive metabolic panel done and a CBC with differential. A functional med doctor I know online took a quick look at the results and said:
- I have suboptimal hemoglobin
- positive for thyroid peroxidase antibodies (I'm Hashi's/hypothyroid, on 100mcg levothyroxine)
- possible zinc deficiency from my alkaline phosphate level (40)
- possible B6 deficiency given my ALT below 10 (8)
- creatinine is low (0.6) although she said my small frame might account for it
- kidneys look great
- albumin above 4.0 (4.7) - encouraging
- red blood cells appear a bit bigger than they should be. Could possibly indicate lack of stomach acid (I do have GERD)
My confusion lies in what do I address first? Before I noticed my CBS mutation I started to take glutathione (50mg) -- then stopped after about 3-4 weeks when realizing it might be a huge mistake. Since then, I've noticed my cognitive issues gotten so much worse. I worry that I screwed myself somehow with trying to fix the methylation cycle/glutathione first
My biggest issue is the brain fog/cognitive issues/memory. The fatigue is dealable right now, especially with Vyvanse (30mg). I have no gut or digestive issues bothering me. Even though I have GERD I never get heartburn. I just have issues swallowing pills from it -- so finding supplements I can take are more difficult since some only come in big pill form
Does it appear my CBS mutations are affecting me? I am willing to try the strict low sulfur diet if it seems like it would help. I bet I also need a heavy metals detox -- mostly mercury -- as I used to have a mouthful of fillings. They were all removed over the years but not with detox in mind.
My current protocol:
- levothyroxine 100mcg
- vitamin D 4000 IU (for the winter -- erased all winter depression which is awesome)
- methyl B-12 5000mg
- 400 metafolin
- 1 baby aspirin
- COQ10 100mg
- zinc citrate/gluconate 25mg
Any recommendations for what to tackle first? Should I bother investing in sulfate strips? I'm totally lost and overwhelmed and having cognitive issues isn't helping lol. Any crucial testing I need done? Money is a bit of an issue but if it's essential I can probably swing it. Hopefully a new me in 2014 ...
Thank you all
Methylation:
Heterozygous mutations (+/-)
- VDR Bsm
- VDR Taq
- MAO A R297R
- MTHFR C677T
MTHFR A1298C
- MTR A2756G
- MTRR A66G
- MTRR R415T
- MTRR A664A
- CBS C699T
- CBS A360A
Homozygous mutations (+/+)
- CYP1B1 L432V
- CYP1B1 R48G
- CYP2D6 S486T
- CYP2D6 2850C>T
- GSTP1 I105V
- CYP2C9*3 A1075C
- CYP2E1*B 9896C>G
- SOD2 A16V
- NAT2 I114T
- NAT2 R197Q
*GSTT1 present
I also looked up SUOX on my 23andme and came up with CT for SUOX (rs705703) and ACE (rs4343) as AG. I'm assuming that means I'm heterozygous for both?
I had bloodwork done in early August and late October.
Vitamin D: 68 (Aug) and 38.3 (Oct).
- supplemented 2000 IU the entire time, only difference -- lost an hour of being out in the sun daily with the colder weather
B-12: 630 (Aug) and 1878 (Oct). Three-fold jump?! In September I switched to Jarrow methyl B-12 5000mg and 800 Solgar folate. Frustration level plummeted, anxiety went sky high so I cut the dosage in half and seem to tolerate it. It makes me wonder if the B12 is that high because it's going nowhere ...
In August they also ran the following:
Folate RBC
- hemocrit: 37.0
- rbc folate: 698
I also had a comprehensive metabolic panel done and a CBC with differential. A functional med doctor I know online took a quick look at the results and said:
- I have suboptimal hemoglobin
- positive for thyroid peroxidase antibodies (I'm Hashi's/hypothyroid, on 100mcg levothyroxine)
- possible zinc deficiency from my alkaline phosphate level (40)
- possible B6 deficiency given my ALT below 10 (8)
- creatinine is low (0.6) although she said my small frame might account for it
- kidneys look great
- albumin above 4.0 (4.7) - encouraging
- red blood cells appear a bit bigger than they should be. Could possibly indicate lack of stomach acid (I do have GERD)
My confusion lies in what do I address first? Before I noticed my CBS mutation I started to take glutathione (50mg) -- then stopped after about 3-4 weeks when realizing it might be a huge mistake. Since then, I've noticed my cognitive issues gotten so much worse. I worry that I screwed myself somehow with trying to fix the methylation cycle/glutathione first
My biggest issue is the brain fog/cognitive issues/memory. The fatigue is dealable right now, especially with Vyvanse (30mg). I have no gut or digestive issues bothering me. Even though I have GERD I never get heartburn. I just have issues swallowing pills from it -- so finding supplements I can take are more difficult since some only come in big pill form
Does it appear my CBS mutations are affecting me? I am willing to try the strict low sulfur diet if it seems like it would help. I bet I also need a heavy metals detox -- mostly mercury -- as I used to have a mouthful of fillings. They were all removed over the years but not with detox in mind.
My current protocol:
- levothyroxine 100mcg
- vitamin D 4000 IU (for the winter -- erased all winter depression which is awesome)
- methyl B-12 5000mg
- 400 metafolin
- 1 baby aspirin
- COQ10 100mg
- zinc citrate/gluconate 25mg
Any recommendations for what to tackle first? Should I bother investing in sulfate strips? I'm totally lost and overwhelmed and having cognitive issues isn't helping lol. Any crucial testing I need done? Money is a bit of an issue but if it's essential I can probably swing it. Hopefully a new me in 2014 ...
Thank you all