Washington Post article, 8/17/23 - by Brian Vastig - re NIH breakthrough re WASF3

[datadragon]

One thing you might want to look into are Sigma 1 agonists. Sigma 1 agonists are being trialed for Huntington’s as ER stress inhibitors and if I’m not mistaken Fluvoxamine has shown promise for COVID/LC due to its Sigma 1 agonism

I would look at that closer as I only had a moment to look. The below suggests Sigma 1 can induce pain and ER Stress. That may be good for certain things but perhaps not for reducing exercise intolerance ME/CFS by reducing ER Stress.

CBD activation of TRPV1 induces oxidative signaling and subsequent ER stress in breast cancer cell lines​

https://pubmed.ncbi.nlm.nih.gov/33604949/

and

TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Here we show that TRPV1 physically interacts with the Sigma 1 Receptor (Sig-1R), a chaperone that binds progesterone, an antagonist of Sig-1R and an important neurosteroid associated to the modulation of pain. Antagonism of Sig-1R by progesterone results in the down-regulation of TRPV1 expression in the plasma membrane of sensory neurons and, consequently, a decrease in capsaicin-induced nociceptive responses. This is observed both in males treated with a synthetic antagonist of Sig-1R and in pregnant females where progesterone levels are elevated. https://www.pnas.org/doi/10.1073/pnas.1715972115 From my post here: https://forums.phoenixrising.me/thr...acute-pain-nejm-08-03-2023.90696/post-2442397

 

[Violeta]

@Violeta Be careful with Berberine it can cause low Blood sugar and GI side effects. That’s an intimidating list of agonists there jeez, I promise there are sigma 1 agonists that aren’t schedule 1 narcotics lol. Pregnenolone, DHEA, Resveratrol, Bromantane/Memantine, etc.

Andrographis might be a better way to go than berberine for me because I do have low blood pressure problems. I see andrographis helps with ER stress via reducing oxidative stress, let me see if it has an effect on blood pressure.

Oh no, please ignore this message.

 

[leokitten]

@Violeta One thing you might want to look into are Sigma 1 agonists. Sigma 1 agonists are being trialed for Huntington’s as ER stress inhibitors and if I’m not mistaken Fluvoxamine has shown promise for COVID/LC due to its Sigma 1 agonism

The COVID-OUT DBRCT comparing metformin, fluvoxamine, and ivermectin on the risk of developing LC in COVID patients found that only metformin reduced risk, fluvoxamine and ivermectin had no effect.