Free full text:
http://qjmed.oxfordjournals.org/content/early/2013/03/28/qjmed.hct061.full
pdf- http://qjmed.oxfordjournals.org/content/early/2013/03/28/qjmed.hct061.full.pdf html
(The comparison trial is the PACE Trial)
*I gave each sentence its own paragraph
http://qjmed.oxfordjournals.org/content/early/2013/03/28/qjmed.hct061.full
pdf- http://qjmed.oxfordjournals.org/content/early/2013/03/28/qjmed.hct061.full.pdf html
(The comparison trial is the PACE Trial)
Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database.
QJM. 2013 Mar 28. [Epub ahead of print]
Crawley E, Collin SM, White PD, Rimes K, Sterne JA, May MT; CFS/ME National Outcomes Database.
From the Centre for Child & Adolescent Health, School of Social & Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, Department of Psychology, University of Bath, Claverton Down, Bath BA2 7AY and School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.
Abstract*
Background:
Chronic fatigue syndrome (CFS) is relatively common and disabling.
Over 8000 patients attend adult services each year, yet little is known about the outcome of patients attending NHS services.
AIM:
Investigate the outcome of patients with CFS and what factors predict outcome.
DESIGN:
Longitudinal patient cohort.
METHODS:
We used data from six CFS/ME (myalgic encephalomyelitis) specialist services to measure changes in fatigue (Chalder Fatigue Scale), physical function (SF-36), anxiety and depression (Hospital Anxiety and Depression Scale) and pain (visual analogue pain rating scale) between clinical assessment and 8-20 months of follow-up.
We used multivariable linear regression to investigate baseline factors associated with outcomes at follow-up.
Results:
Baseline data obtained at clinical assessment were available for 1643 patients, of whom 834 (51%) had complete follow-up data.
There were improvements in fatigue [mean difference from assessment to outcome: -6.8; 95% confidence interval (CI) -7.4 to -6.2; P < 0.001]; physical function (4.4; 95% CI 3.0-5.8; P < 0.001), anxiety (-0.6; 95% CI -0.9 to -0.3; P < 0.001), depression (-1.6; 95% CI -1.9 to -1.4; P < 0.001) and pain (-5.3; 95% CI -7.0 to -3.6; P < 0.001).
Worse fatigue, physical function and pain at clinical assessment predicted a worse outcome for fatigue at follow-up.
Older age, increased pain and physical function at assessment were associated with poorer physical function at follow-up.
CONCLUSION:
Patients who attend NHS specialist CFS/ME services can expect similar improvements in fatigue, anxiety and depression to participants receiving cognitive behavioural therapy and graded exercise therapy in a recent trial, but are likely to experience less improvement in physical function.
Outcomes were predicted by fatigue, disability and pain at assessment.
PMID:23538643[PubMed - as supplied by publisher]
*I gave each sentence its own paragraph