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i dont know @sarah darwins
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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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one would think, you would have low iron, with infection?
Heparin's normal role in the body is unclear. Heparin is usually stored within the secretory granules of mast cells and released only into the vasculature at sites of tissue injury. It has been proposed that, rather than anticoagulation, the main purpose of heparin is defense at such sites against invading bacteria and other foreign materials.
Wild speculation welcome.
Nice detective work, Jaime. Out of curiosity, have you experimented with saccharomyces boulardii? I've been reading some things lately that suggest it helps with various healthy gut flora and is very prophylactic both during and soon after antibiotic treatment (Horowitz is very keen on it, and far from alone). Might be a bit less of an insult to the system than regular probiotics.
I've been doing a lot of research on iodine these days, and benefitting a lot of iodine supplementation. So I tend to view a lot of things through that lens at the moment.
I don't know really, but I've read that pathogens and even cancer cell utilize iron for growth.
I'm hesitant to waste money when I've tried 'maybe THIS probiotic won't bother me' three times in a row...
I'm hesitant to waste money when I've tried 'maybe THIS probiotic won't bother me' three times in a row...
In summary, human pathogens have evolved a plethora of mechanisms to obtain host iron. In response to infection, the innate immune system further strengthens iron-withholding defenses, ensuring that the host-pathogen interface remains an ever-evolving battleground for precious metal.
Bacteria like iron, and proliferate when it's abundant; but lactoferrin has to have iron to help produce an effective immune response. There is a really good summary article on infection as it relates to iron here:
Cassat JE, Skaar EP. Iron in Infection and Immunity. Cell host & microbe. 2013;13(5):509-519. doi:10.1016/j.chom.2013.04.010.
-J
So, you don't disagree that this condition may have an infectious cause?
I don't know for sure, now I'm back to high dose goldenseal tincture because it seems I've left some rascals behind after abx. (e coli ?)
http://umm.edu/health/medical/altmed/herb/goldenseal
Theoretically, goldenseal and berberine could increase the risk of bleeding
I think I might have found a potential culprit: heparin. My own.
Heparin, a blood thinner, is produced by mast cells. Presumably this is more pronounced when infection is severe.
It's a defense mechanism. It's certainly only happened when I'm at my sickest, so we may have our answer. Or at least a tentative hypothesis that makes relative sense -- the most we can generally hope for!
To further support this hypothesis, my most recent bout of bleeding happened when I stopped my most recent antibiotic, and stopped once I bit the bullet and began consuming small amounts of probiotics. I don't do well with them, neurologically, but my digestive system is way happier with me right now... and I'm not bleeding like a hemophiliac anymore.
-J
The anaemia of inflammation (anaemia of chronic disease) is the result of increased hepcidin expression induced by inflammatory cytokines which is generally considered to be a host response that evolved to make iron less available to pathogens. This condition is characterized by decreased release from iron stores, low plasma iron and transferrin concentrations, restriction of the available iron supply for red blood cell production and mild or moderate anaemia.
@sarah darwins - I tried the Sacromyces, half a pill, and it's the first probiotic that does not appear to make me sicker. Thank you!