Been looking at Metanx and the differences in the vitamin components as compared to recommendations found on this site. I don't have CF but do suffer from SFPN and am looking for a helpful protocol.
As you can see below, the formula emphasizes the Methylfolate with 6 mg a day (in 2 tablets) and only 4mg of Methylcobalamin. This is way more than the 800mcg - 2 or 3mg recommended in most of the protocols here on Phoenix Rising. I have to assume 6mg a day of methylfolate would be safe as these levels are taken by patients prescribed this medical food product. As you can see below, 2 studies I've found indicated actual nerve regeneration with this product. (Although not sure if studies were funded by pharma co. or not)
Seems like these dosages could be replicated with individual products instead of taking Metanx per se.
Would appreciate an board thoughts on Metanx or in particular taking dosages of LMF as high as
6mg a day which seems to be much more than anyone on this site is suggesting. Must say findings of actual nerve regeneration to be intriguing.
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Metanx® tablets are indicated for the distinct nutritional requirements of patients with endothelial dysfunction21-23 who present with loss of protective sensation13 and neuropathic pain24-26associated with diabetic neuropathy.
The usual adult dosage of Metanx® is one tablet twice daily and it is OK to take both tablets at the same time.
L-methylfolate Calcium (as Metafolin®)3mg
Pyridoxal 5′-phosphate35mg
Methylcobalamin2mg
http://www.metanx.com/helpful-resources/metanx-quick-facts/
Study indicates Metanx increases intraepidermal nerve fiber density.
http://diabetes.diabetesjournals.org/content/early/2012/05/14/db11-1524.short
Another Study shows 73% of patients show increased ENFD, 82% of patients - reduced pareesthsia
http://www.ncbi.nlm.nih.gov/pubmed/21769070
As you can see below, the formula emphasizes the Methylfolate with 6 mg a day (in 2 tablets) and only 4mg of Methylcobalamin. This is way more than the 800mcg - 2 or 3mg recommended in most of the protocols here on Phoenix Rising. I have to assume 6mg a day of methylfolate would be safe as these levels are taken by patients prescribed this medical food product. As you can see below, 2 studies I've found indicated actual nerve regeneration with this product. (Although not sure if studies were funded by pharma co. or not)
Seems like these dosages could be replicated with individual products instead of taking Metanx per se.
Would appreciate an board thoughts on Metanx or in particular taking dosages of LMF as high as
6mg a day which seems to be much more than anyone on this site is suggesting. Must say findings of actual nerve regeneration to be intriguing.
-------------------------------------------------------------------------------------------------------------------------------
Metanx® tablets are indicated for the distinct nutritional requirements of patients with endothelial dysfunction21-23 who present with loss of protective sensation13 and neuropathic pain24-26associated with diabetic neuropathy.
The usual adult dosage of Metanx® is one tablet twice daily and it is OK to take both tablets at the same time.
L-methylfolate Calcium (as Metafolin®)3mg
Pyridoxal 5′-phosphate35mg
Methylcobalamin2mg
http://www.metanx.com/helpful-resources/metanx-quick-facts/
Study indicates Metanx increases intraepidermal nerve fiber density.
http://diabetes.diabetesjournals.org/content/early/2012/05/14/db11-1524.short
Another Study shows 73% of patients show increased ENFD, 82% of patients - reduced pareesthsia
http://www.ncbi.nlm.nih.gov/pubmed/21769070