http://news.wustl.edu/news/Pages/St...-way-to-boost-immunity-and-fight-viruses.aspx
Interesting article. Perhaps this will help ME/CFS patients....
Interesting article. Perhaps this will help ME/CFS patients....
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Pretty interesting, especially in the context of enteroviruses (the encephalomyocarditis virus they were using in the study is also a picornavirus). I've been thinking for a while that interference with the STAT1 pathway might be part of why these chronic enterovirus infections in ME can persist for so long. One of the enterovirus proteases interferes with the IFNAR/STAT1/ISG pathway so even in the presence of elevated interferon, the infected cell might be unable to turn on it's innate antiviral pathways. It looks like what they did in this study is boosted expression of STAT1 which likely boosted transcription of the inteferon stimulated genes. Perhaps that helps work around this viral countermeasure.http://news.wustl.edu/news/Pages/St...-way-to-boost-immunity-and-fight-viruses.aspx
Interesting article. Perhaps this will help ME/CFS patients....
Years ago docs used interferon to treat CFS
Now cycloferon, that some use, is an interferon inducer. So it makes sense that this would have benefits for us.
Were you taking these with anything that would boost production of IFN α or β?I took all the above supplements once daily for a total of 22 days. However, I noticed no improvements in any ME/CFS symptoms.
Were you taking these with anything that would boost production of IFN α or β?
Wonder how it would change things to throw a translation inhibitor like amantadine in that mix.
Hopefully this research will lead to STAT1 inducing drug.
But oral tretinoin used to treat leukemia can have serious and fatal side effects. Even topical tretinoin (used for acne) has apparently been associated with fatalities.Treatment of freshly isolated acute promyelocytic leukemia (APL) cells and the myelogenous leukemia cell lines, NB4, HL-60, and U937, with all-trans retinoic acid (ATRA) results in a remarkable elevation in the amounts of Stat1 alpha and Stat2 proteins.