@detharlwy @dead.money
OK somewhere in cyberspace floats my original reply ....
Anyway, hi. I don't get to this site very often anymore as I have recovered from Bipolar by treating mercury toxicity and have made an 80% recovery from ME by addressing my methylation issues.
I am going to make some general comments but I seem to be on a unique path and what I say may have little relevance to your situation.
By the time we get to where we are we'll have to accept that there are no more easy answers...no silver bullets, and no magic elixirs that will bring back what we had.
We are caught up in a dance and are spun from partner to partner..... infections (1 - 2- 3 4+), digestive problems malabsorption, dysbiosis and leaky gut. Altered and pissed-off immune systems, autoimmune, endocrine.....and the dance goes on and on....
n=1 is hardly creates a platform of authority. To complicate things further I have had to dance with multiple partners at the same time and sometimes am not sure what it was that ultimately helped. But I will share my guesses with you. And some of these I refer to as the "rungs in my ladder".
My personal story speaks to Bipolar and ME occurring in one individual. Both have low glutathione theories as does Hyperplastic Polyposis (100+ polyps, colon out in 2013). Glutathione production relies upon a methylation system that is getting things done.
What else relies on methylation? BH4 production - a co-factor for the conversion of amino acids to neurotransmitters and tyrosine to T4 and ultimately T3.
Repairs of myelin sheaths = proper neuron function. My dance partners are lining up
My diagnosis was Brittle Rapid-Cycling Bipolar II, Mixed States.
- I think that it responded to the thyroid meds. My Dr wouldn't treat - my TSH was 3.x and there were some antibodies. The first I got on board was taken from my wife's script.
- everyone with Bipolar and methylation problems should be checked for heavy metal toxicity. There is no reason to expect optimal recovery from anything but particularly a psychiatric diagnosis if there are toxins on board. This may, or may not be especially true if a person does not respond as expected to Bipolar meds. Treating mercury toxicity with antipsychotics will never be more than partially effective.
- mercury interferes with the availability of glutathione a number of ways. Low glutathione has been linked to expression of bipolar symptoms
- mercury is stored in astrocytes making them sick. Astrocytes convert T4 to T3 (active form) for the neurons
- highest concentration of T3 receptor sites in limbic and norepinephrine systems. Both key in bipolar.
Methylation is tricky. There are those with Bipolar who do not tolerate B12 etc. It revs them and/or makes them irritable. COMT (magnesium is your friend) will aggrevate this. I could not get enough mB12 and I am left wondering if this in anyway has to do with moving against mercury for 18 months (and suffering) first.
The is all conjecture. But since mercury messes up methionine synthase and this is where B12 is a co-factor, maybe |by removing enough mercury B12 was able to do what it needed to. It doesn't help to keep pouring gas in if the motor ain't running.
(I also am TCN2++ and have other transport issues. While there is little to prove that this has a major impact on transport into the cells that I am aware of, it certainly has been shown in studies to be related to frailty. There is something going on with it alone or in combination with other genetic/epigenetic factors IMHO).
So that's it. I can go on and on but I bore myself. Yes, when you recover to a certain point, you will get tired about thinking of your health. And I want to end this (I will come back to see if anyone has questions) with a comment. My personality changed. I am on hydrocortisone as mercury took out my adrenals and it does not pay for me to get too excited about the little stuff.
I also lost that suspicious aspect of my thinking where I suspected other's motives. I used to be very quick to take offence or make the wrong assumptions about people and their intentions. Always on edge and waiting for the next reason to jump to conclusions and that was a mercury thing.
Get Amalgam Illness by Cutler there is a description of the mercury personality that will really hit home for some.
Probably left more questions than answers behind.... brad
