@pamojja
Sorry, I'm trying to make sense of your history but I can't get the dates straight from what you wrote.
In 2009 you seem to have a picture consistent with iodine deficiency.
..Then in 2010 you go low carb. Is that also the year when you went on iodine first?
Some of those years you are taking thyroid extract which would throw your labs off. I think you need to enter what you were taking every year into your chart in order to see the full picture.
I took the 80mg, almost 1/3 of a capsule of
Swanson Thyroid Glandular (Thyroxine Free) during the years indicated.
(80mg during the 3.- 5. year, and again from 7. to now)
But it never ever made any difference to my before and after thyroid lab results, or how I felt in any way. I can be stubborn
I have every lab test entered in a google-spreadsheet, in a second all nutraceuticals I've taken throughout all this time. It's just too large, complex and would rather not post a link publicly. But if you're really indent on sifting through so much of overwhelming data - the big picture is really vast - I could PM you the link if you really wanted.
To be precise with the iodine-intake: in the period of 8.2009-3.2010 about 0.7 mg, 4.-11.2010 about 5 mg, 12.2010-7.2011 about 12mg per day - each recorded period 8 month in length, actually always gradually increasing for catching possible adverse event (which I never had), along with numerous other vitamins, minerals and phyto-nutrients.
You also might want to think about any new prescription medications that you went on in 2009/2010. Statins, for example, have been known to precipitate CFS in some people through CoQ10 depletion.
Never took prescribed meds. However, had numerous nutrient-deficiencies, also CoQ10. Which I realized only when starting to supplement 9 years ago, because always above 150 mg CoQ10 (half the dose with Ubiquinol) made terrible stress related (physical or mental) angina-like chest pains go away.
Vitamin D excess can decrease D1 expression and affect thyroid sensitivity so that could have played a role too
https://www.ncbi.nlm.nih.gov/pubmed/20097959
In female Sprague-Dawley rats with 1-methyl-1-nitrosourea (MNU)-induced carcinogenesis of mammary glands. I've been mostly vitamin D deficient, and the curve of my serum 25(OH)D does't seem to correlate with my curve of expression or sensitivity.
You should also look into ayurvedic herbs you were taking, a lot of them have effect on hypothalamic and thyroid function so it may provide some clues as well.
Beside many other benefits on all body systems, that's why I take them.
If you want to stay low carb then try to do high fat/ high protein diet. Bile acids can be taken as a supplement and seem to have effect on Dio2 expression. Guggul extract (herb) can increase peripheral T3 conversion.
Got about 68% of my calories from healthy fats, my weight never changed a jota (BMI of 20). Have been on Guggul extract since the beginning gradually increasing to 1.1 g/d till 2013 and staying at that dose since then..
End of 2015/ beg 2016 you were not producing as much T4. Were you feeling better then? What were you doing differently?
That was the time of my PAD-symptoms remission (peripheral arterial disease, usually considered non-reversible) and that alone of course made me feel hell of a lot better then. Less the realization that all along there were ME/CFS symptoms and now remaining. Did not do really much different, therefore accrued it to the synergistic effects of years in life-style modifications and supplementation. So yes, much joy about having remission with a non-reversible disease, but still all ME/CFS symptoms remaining as before.
Just realized that I actually already published my nutrient intake google-spreadsheet on an
other forum post, where you could find a link to it. Also an analysis of all my substantial nutrient-intake increases before that significant remission in an additional post there.
Cortisol (may be related to your work stress) and estrogen (which may be affected by DHEA, pregnenolone) can also have an effect on peripheral deiodination.
The problem in my case everything synergistically does have effects (PAD, COPD, T2D, CKD, stroke, enlarged liver and spleen, numerous nutrient deficiencies). And that in dodo has of course repercussions on hormones too. I warned about the complexity, but here the hormonal piece to the puzzle:
So cortisol at that time has indeed been lowest in serum, highest in 24hrs urine. DHEAs highest ever. Estradiol normal. Nothing related to anything I did particularly different that time.
You said T3 didn't change your labs but did you feel better on it? Did you take 20 mcg all at once or in divided doses?
First time took 25mcg tabs sublingual in divided doses, second time the same with drops. Didn't felt a jota different.
Thanks for all your suggestions.