"Hi Todd,
methyl folate can range from 400, to roughly 1600mg a day.. Do you think that low dose of folate would even trigger paradox deficiency? It seems most people that had that were using much higher doses...-Todd
This one you have 100% backwards. A low dose like this almost always triggers donut hole paradoxical folate deficiency. Higher doses relieve it. Low dose methylfolate PFD can cause massive inflammation.
Daily doses of B1 and B2 above 30-50mg a day and B3 above 100mg a day can cause an insatiable need for methylfolate and potassium, so make sure that is ok. Remind me that you are not taking NAC, glutathione or Whey.
If you want to get rid of low folate symptoms and inflammation try 4mg of l-methylfolate or so each 4-6 hours Typically it will start turning around within a few hours and after a day or 3 you should know for sure. Now it is possible you are one of those who needs 30mg a day to make any headway but that is rare without folic acid or folinic acid or large amounts of vegetable folate.
Try 8mg before you go to bed tonight. Metafolin has no side effects different from sugar pills. That is what the Deplin study says at doses up to 30mg/day. Best results are at 15 and 30mg daily. That is what all my experience says. The people who take tiny doses have terrible reactions and think it is because of so much folate instead of so little. They have even worse responses with 200 mcg of folinic and 200mcg of mfolate. Wow do they get hit. That is because of a double whammy paradoxical folate deficiency. Without the folate you are wasting your money and wasting 90% of the b12. You could get equally bad results from 500mcg of b12.
Try it cautiously, 4 mg and then 4rmg in couple of more hours to avoid possible stomach distress or take 8mg and some food and go for it. You could be a new man in 2 days.
After you get rid of all the folate deficiency symptoms, then is the time to adjust other things. Doing it otherwise is bass akwards.
Now this is my opinion and experience. Everybody who takes the small doses has terrible results and a rough time. The people who use the larger doses get healing going. You can always go back but I would
bet
Fred"