There is a good bit of literature relating to mold toxins that suggests that a combination of trichothocenes (especially satratoxin, made by Stachybotrys) and LPS is more damaging than either one alone.
LPS is made by a variety of different sorts of bacteria, including ones in the environment and ones that can be pathogens.
A number of mold avoiders have reported that taking steps to decrease their pathogen load has been effective in decreasing their reactivity a bit. These positive reports have included things that address fungi (homemade kefir/yogurt, antifungal drugs or herbs, certain probiotics), things that address Lyme or other bacteria (doxycycline or other drugs), and things that address viruses (Valcyte, Famvir, other antivirals). I wouldn't be surprised if the improvements that some people report from MAF products work through this mechanism as well.
I've tried all these things and found them to be helpful. However, in terms of really getting my reactivity down (and keeping it down without needing to take any drugs or supplements), the thing that has had the most effect is concerted detox. The amount of toxins that have come out of my body has been quite astounding, especially since I never previously had any idea before pursuing avoidance and detox that toxins were any kind of issue for me at all.
The model that currently makes the most sense to me is that the toxins in the system have an effect on the immune system, allowing a wide variety of pathogens to proliferate. Those pathogens have a wide variety of effects, including increasing reactivity.
In terms of decreasing reactivity fast, addressing the pathogens directly may seem to be the most efficient route. In my own case, I do think that the Valcyte/Famvir was helpful since (I believe) it was responsible for decreasing my reactivity enough that I could live (and detox) in places that were less than absolutely pristine. However, insofar as people have the goal of getting permanently well, detox seems to be the way to go.
I did find cholestyramine helpful, though I only was able to take it early on when in a super-pristine environment. I think a problem with detox for people with this illness is that it can be blocked in a variety of ways, meaning that a multi-pronged approach can be crucial. I've used a wide variety of techniques myself, including things that release toxins from the cells (methylation supplements, other supplements), things that promote the movement of toxins through the lymph (neural therapy, other bodywork), probiotics that neutralize the toxins (homemade kefir/yogurt, certain commercial products), binders that carry the toxins out through the intestines (csm, pectin, bentonite), products that support the liver (supplements, foods, coffee enemas), things that dissolve debris (juicing, enzymes), and energetic treatments (such as the homeopathic mold remedy Natrum Sulphuricum).
I'm increasingly convinced that a good part of the immune dysfunction of this illness comes as a result of the mold toxins causing dysbiosis in the microbiome. Mold makes toxins specifically to kill off other microorganisms in the environment so that it can grow freely. The idea that this toxin would have that same effect inside our system as it does on the walls of our house seems to be just common sense. After all, penicillin and certain other antibiotics are made from mold poison! Except that those types of mold kill off a narrower spectrum of microorganisms than does (say) Stachybotrys.
Here's an article that discusses the importance of the microbiome. (Cheney's been discussing this for a few years too.)
http://www.economist.com/node/21560523?fsrc=scn/tw_ec/me_myself_us
Of course, most specialists in this disease agree that the core immune dysfunction seems to be the low Natural Killer Cell function, which allows the proliferation of herpes family viruses. So far, no one has given any sort of plausible explanation for why this becomes such a problem. My hypothesis here is that the disease gets kicked off when susceptible people are exposed to a particular toxin (e.g. a particular biotoxin) that has a really destructive effect on the NKC's and then cannot expel this toxin from the system. There are papers in the literature that suggest that certain kinds of toxins do have an effect on NKC function, so that kind of speculation does have some sort of grounding. I tend to think it's a particular type of biotoxin (such as the one that we believe to have been specifically associated with the Tahoe epidemic) that's doing this though, rather than all biotoxins. If that's the case, then unless people focus specifically on that toxin, they're not going to get anywhere (and thus will continue to believe that the biotoxin issues are not causal).
As models for the disease go, the one that makes the most sense to me is that the inflammation from the toxins and the herpes viruses activates an endogenous retrovirus (erv). ERV's are thought to play roles in MS and ALS (both of which also appear to be biotoxin diseases). It could be that MS, ALS and CFS have different erv's associated with them, that go active when all that inflammation is present. The epidemiology of CFS is much more consistent with this theory than with the idea that it is being caused by a contagious pathogen, of course.
Best, Lisa