That's probably just as well,
@MeSci, because although I would like to read your views in full, and then cross reference them with other sides of the argument, I just don't have the brain powder to take on board new subject areas like this, as I am sure you appreciate, as a fellow ME/CFS patient. Which is a shame, because I used to enjoy these sort of discussions.
I imagine that the degree of applicability of murine models to human disease will vary from one disease to the next.
Murine models may well be very applicable to studying ME/CFS:
If you look at Profs Nora Chapman and Steven Tracy's
murine models of coxsackievirus B heart muscle infection (myocarditis), it would appear that these models were instrumental in facilitating their discovery of the
non-cytolytic form of enterovirus infections in chronic coxsackievirus B myocarditis; they and Dr Chia think non-cytolytic enteroviruses may play a fundamental role in ME/CFS. Coxsackievirus B actually replicates very well in mice, so mice make good experimental models for studying chronic enterovirus infections.
I don't see why these researchers don't try to inoculate coxsackievirus B into the central nervous system of mice (rather than their heart muscle), to create an experimental model of ME/CFS. I have a hunch that injecting coxsackievirus B into the murine brain may well cause the mice to develop enterovirus-associated ME/CFS, because we know that coxsackievirus B is found in the brains of autopsied ME/CFS patients, but not in the brains of the controls.