In the OMF Syposium video, Prof Mark Davis presented some incredibly interesting stuff regarding T cells. In particular that there is probably a triggering antigen in ME/CFS and that CD8 clonal expansion, similar to that seen in MS & cancer is present in ME/CFS patients.
I always thought Rituximab was designed to deplete B cells alone, but after a quick Google I found this:
Source: https://www.ncbi.nlm.nih.gov/m/pubmed/23918413/
I'm sure some of you may have been aware of this for a while but I found it interesting/exciting given Mark Davis's findings!
I always thought Rituximab was designed to deplete B cells alone, but after a quick Google I found this:
RESULTS: Data on 52 patients were examined. Rituximab induced unexpected and substantial depletion of T cells, mainly CD4+ cells, in most patients...lack of CD4+ cell depletion was associated with no clinical response. Therefore, the mechanism of action of rituximab may depend at least in part on T cells.
CONCLUSION: Rituximab induces substantial T cell depletion, mainly of CD4+ cells, which is associated with the clinical response in RA.
Source: https://www.ncbi.nlm.nih.gov/m/pubmed/23918413/
I'm sure some of you may have been aware of this for a while but I found it interesting/exciting given Mark Davis's findings!