Hi Rich - TY for your analysis. My alt doc is in MA, I'm going in a couple weeks, think I'll see if they can order & run the methylation panel from there. I assume the results will be faster that way than waiting for everything to go to Europe and back? Is any special test kit required, or can we just send standard blood draws from MA and have HD take care of it using those & a credit card #?
In the meantime, think I will reduce mb12 even more, down to around 1mg, with the intent of switching over to hydroxy as soon as I can order and receive that. Without the sublingual mb12, my b12 was almost totally wiped out, but I was also on the omeprazole at that time, so it's hard to say if it's from intrinsic factor deficiency or b/c of the drug. Either way, think I feel more comfortable with hydroxy at this point, as the IVs I had with mb12 seemed to cause side effects, the first time even lasting for a couple weeks. The hydroxy IVs by contrast have been fine.
I didn't think folate conversion was an issue for me, b/c I get the same super low heart rate and depression symptoms both from methylfolate and standard folic acid. But maybe there is some issue there slowing down conversion, which I suppose is very hard to say w/out the meth panel. Otoh, I don't seem to get those symptoms from the folate in the B-right, strangely enough, which is why I was taking that - to at least be getting some supplemental folate. If it's not converting though, or converting too slowly to be effective, I guess it's just counterproductive at this point, and I should dump the B-right for one of the non-folate B-complexes and start micro-dosing the methylfolate.
Does all that sound right, or at least reasonable? : P Was hoping to avoid the methylation panel b/c of the expense, but it might be better to just put all guesswork aside and know for sure. Can you say with certainty that there would be distinct advantages from a treatment standpoint from having the test, as opposed to just trial and error and seeing what works clinically, and with standard labs guiding me as far as the folate & b12 levels?
Btw, I also have low CD8, high EBV, and some other infections - mycoplasma pneumoniae, etc. Think we're going to work on treating those at my next visit, as I'm sure those are playing into this presumed GSH-depletion problem, also.