Snow Leopard
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Thanks Snow Leopard. I need to study these papers in detail. But if, as I am suggesting, peripheral receptors are blocked but hypothalamic receptors are not, then could one have sensitivity to steroid in a suppression test but resistance in terms of peripheral physiology? Autoantibodies often produce paradoxical effects on function.
It is possible, but unlikely, given that similar findings have been found from in-vitro testing of blood cells.
Cleare 2003 said:In vitro studies of feedback provide further support for enhanced GR sensitivity. Visser et al. (69) looked at CD4-positive T cells from a small group of subjects with CFS. They found that a lower concentration of dexamethasone was needed to inhibit CD4 function, suggesting increased sensitivity to dexamethasone. Visser et al. (70) followed up this study by measuring GR function directly on the peripheral blood mononuclear cells of 10 subjects with CFS and 14 controls. Although there was no difference in GR affinity or number, or of GR mRNA expression, the peripheral blood mononuclear cells from patients with CFS were again more sensitive to dexamethasone, suggesting an abnormality in signal transduction beyond the level of receptor binding.
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