Countrygirl
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Well, this new paper is enough to make me reach for my smelling salts.............and to pop another blood pressure pill.............to ward away a fit of the vapours.
How can there be people who still write this nonsense? Well, may they keep digging their hole into which they should soon disappear.....................
For the masochists amongst us you can even purchase the full document, while for the mentally well balanced, it could provide a bit of entertainment and a chuckle..............maybe even a bit of sympathy for the misguided individuals who write this stuff.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Available online 12 February 2018
In Press, Accepted ManuscriptWhat are Accepted Manuscript articles?
Archival Report
Fatigue is associated with altered monitoring and preparation of physical effort in patients with chronic fatigue syndrome
Author links open overlay panelMarieke E.van der Schaaf12KarinRoelofs2Floris P.de Lange2Dirk EM.Geurts5Jos WM.van der Meer4HansKnoop13∗IvanToni2∗
1
VU University Medical Center, Department of Medical Psychology, Expert Center for Chronic Fatigue, Amsterdam Public Health research institute, Amsterdam, the Netherlands
2
Radboud University, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, The Netherlands
3
Academic Medical Centre (AMC), University of Amsterdam, Department of Medical Psychology, Amsterdam, the Netherlands
4
Radboud University Medical Centre, Department of Internal Medicine, Nijmegen, The Netherlands
5
Radboud University Medical Centre, Department of psychiatry, Nijmegen, The Netherlands
Received 8 November 2017, Revised 9 January 2018, Accepted 9 January 2018, Available online 12 February 2018.
Show less
https://doi.org/10.1016/j.bpsc.2018.01.015Get rights and content
Abstract
Background
Chronic fatigue syndrome (CFS) is characterized by disabling fatigue, which is suggested to be maintained by dysfunctional beliefs. Fatigue and its maintenance are recently conceptualized as arising from abnormally precise expectations about bodily inputs and from beliefs of diminished control over bodily states, respectively. This study uses functional neuroimaging to identify the neural correlates of fatigue and its maintenance by beliefs during a physical effort task.
Methods
We isolate behavioural adjustments and cerebral activity during feedback processing and motor preparation, in the context of a task where CFS patients (N=85) and healthy controls (N=29) produced 30%, 50%, and 70% of their right hand maximal voluntary contraction (MVC), and received directional feedback on performance (e.g. “too little force”).
Results
CFS patients showed an effort-dependent behavioural bias towards less effort investment in response to directional feedback for the highest effort level as compared to HC. This bias was associated with reduced feedback-related activity in the DLPFC. These effects were proportional to state-related fatigue and prior beliefs about their ability to perform the task within CFS patients. CFS patients also showed higher activity in the supplementary motor area (SMA), proportional to their state-related fatigue, and reduced connectivity between SMA and sensorimotor cortex during motor preparation as compared to controls.
Conclusions
These findings link fatigue symptoms to alterations in behavioural choices on effort investment, prefrontal functioning and SMA connectivity, with the DLPFC being associated with prior beliefs about physical abilities.
Keywords
Psychosomatic symptoms
Effort
Functional MRI
Prior beliefs
Dorsolateral prefrontal cortex
Supplementary motor area
Choose an option to loc
How can there be people who still write this nonsense? Well, may they keep digging their hole into which they should soon disappear.....................
For the masochists amongst us you can even purchase the full document, while for the mentally well balanced, it could provide a bit of entertainment and a chuckle..............maybe even a bit of sympathy for the misguided individuals who write this stuff.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Available online 12 February 2018
In Press, Accepted ManuscriptWhat are Accepted Manuscript articles?
Archival Report
Fatigue is associated with altered monitoring and preparation of physical effort in patients with chronic fatigue syndrome
Author links open overlay panelMarieke E.van der Schaaf12KarinRoelofs2Floris P.de Lange2Dirk EM.Geurts5Jos WM.van der Meer4HansKnoop13∗IvanToni2∗
1
VU University Medical Center, Department of Medical Psychology, Expert Center for Chronic Fatigue, Amsterdam Public Health research institute, Amsterdam, the Netherlands
2
Radboud University, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, The Netherlands
3
Academic Medical Centre (AMC), University of Amsterdam, Department of Medical Psychology, Amsterdam, the Netherlands
4
Radboud University Medical Centre, Department of Internal Medicine, Nijmegen, The Netherlands
5
Radboud University Medical Centre, Department of psychiatry, Nijmegen, The Netherlands
Received 8 November 2017, Revised 9 January 2018, Accepted 9 January 2018, Available online 12 February 2018.
Show less
https://doi.org/10.1016/j.bpsc.2018.01.015Get rights and content
Abstract
Background
Chronic fatigue syndrome (CFS) is characterized by disabling fatigue, which is suggested to be maintained by dysfunctional beliefs. Fatigue and its maintenance are recently conceptualized as arising from abnormally precise expectations about bodily inputs and from beliefs of diminished control over bodily states, respectively. This study uses functional neuroimaging to identify the neural correlates of fatigue and its maintenance by beliefs during a physical effort task.
Methods
We isolate behavioural adjustments and cerebral activity during feedback processing and motor preparation, in the context of a task where CFS patients (N=85) and healthy controls (N=29) produced 30%, 50%, and 70% of their right hand maximal voluntary contraction (MVC), and received directional feedback on performance (e.g. “too little force”).
Results
CFS patients showed an effort-dependent behavioural bias towards less effort investment in response to directional feedback for the highest effort level as compared to HC. This bias was associated with reduced feedback-related activity in the DLPFC. These effects were proportional to state-related fatigue and prior beliefs about their ability to perform the task within CFS patients. CFS patients also showed higher activity in the supplementary motor area (SMA), proportional to their state-related fatigue, and reduced connectivity between SMA and sensorimotor cortex during motor preparation as compared to controls.
Conclusions
These findings link fatigue symptoms to alterations in behavioural choices on effort investment, prefrontal functioning and SMA connectivity, with the DLPFC being associated with prior beliefs about physical abilities.
Keywords
Psychosomatic symptoms
Effort
Functional MRI
Prior beliefs
Dorsolateral prefrontal cortex
Supplementary motor area
Choose an option to loc