lansbergen
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[my bolding]
Surely that is neither legal nor ethical. I suspect a myth or misunderstanding.
Even worse if he did it in the placebo group.
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[my bolding]
Surely that is neither legal nor ethical. I suspect a myth or misunderstanding.
[my bolding]
I suspect a myth or misunderstanding.
These findings show that cognitive factors and conditioning are balanced in different ways in placebo analgesia, and this balance is crucial for the activation of opioid or nonopioid systems. Expectation triggers endogenous opioids, whereas conditioning activates specific subsystems. In fact, if conditioning is performed with opioids, placebo analgesia is mediated via opioid receptors, if conditioning is performed with nonopioid drugs, other nonopioid mechanisms result to be involved.
These findings show that cognitive factors and conditioning are balanced in different ways in placebo analgesia, and this balance is crucial for the activation of opioid or nonopioid systems. Expectation triggers endogenous opioids, whereas conditioning activates specific subsystems. In fact, if conditioning is performed with opioids, placebo analgesia is mediated via opioid receptors, if conditioning is performed with nonopioid drugs, other nonopioid mechanisms result to be involved.
I would be really really really surprised if this turned out to be true, this is a truly novel claim.
The alternative (and simpler) explanation is what I have been proposing. (that their observations are due to other biases).
This systematic review assesses six experimental studies into the mechanism of placebo analgesia in human subjects suffering from clinical pain or experimentally induced ischaemic arm pain. Due to their sophisticated designs, these studies probably provide the best evidence that placebo analgesia exists. They also indicate that placebo analgesia is mediated by endogenous opiates. However, there seems to be room for additional studies.
What!? You, too?or my crappy memory
Yeah but the 'correlation does not equate to causation' mantra gets a bit silly and extreme too.
Clear thinking is important. I had wondered too if the 'saline solution' did contain some poisons which is rife in the placebos.
But whilst the article discusses the book Mind Over Medicine, I think the Doctor who wrote that maybe suppying the references.
I don't know if the study you quote snowleapord is the one referenced by the Doc.
It would be good to have honest raw data.
Better, to view it direct.
It could all be another myth designed on lies.
Even less unexpected is the observation that there was no statistically significant difference in the chances of being pain-free at the 2.5 hour time point between the no-treatment control and the open-label placebo group. This is entirely consistent with what we’ve been arguing here at SBM for a long time, that the more “objective” or “hard” the endpoint (and, although there is still a subjective component, being pain-free is a harder endpoint than stating a pain score), the weaker any placebo effects observed are, to the point that the very “hardest” endpoints, such as tumor regression or survival, are not affected by placebo.
CONCLUSIONS: A placebo response, ie, a reduced pain level, was seen in the Placebo group at 15 minutes after the injection. The placebo response was not related to stress or to beta-endorphin. Expectation of a pain increase in the Nocebo group led to an increase in cortisol, but the expectation of pain increase and the resultant cortisol increase had no effect on pain.