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started to feeling sick 3 years ago,
1 week after an abx course, i think, that was just the trigger, i think i had the issues before but not at the point to feeling sick.
the first i felt was sudden histamine intolerance, without reason, just connected the points, i were feeling so bad after eating.
histamine intoelrance in now my worst isuue, it bothers me more than other thing, i cant handle it more...sincerely, i dont know what more try. any help will be much more that apreciatted, im advanced sufferer so, i know almost all have to be known.
i dont have DAO issues, tested and my DAO activity is perfect, and tried DAO supplements, and nothing...
so i have to think that my issue is due to HNMT (as almost all mi issues depends on methyl transferase etc, its all about methylation, i know)...but.... HNMT depends on SAME as methyl donnor, and ...when tried supplementing same i felt really sick, as much as in the beggining, not histamine, just sick sick (didnt tried histamines to be honest, but it send me back 1000 steps ) so...what i lost here? i dont understand that.
my other issues, when started to be sick were, ultra low blood pressure, POTS, insomnia, big brain fog, big anxiety, difficulty walking...now, i know all them could be due to histamine overload, today, im much better of almost all those, except MAO/COMT relative symptoms.
as well, i have problems with medicines/supplements.... much less than a quarter of recommended doses gives me a big effect..so i think i have 2 options:
1. cyp2d6 /p450 issues
2. leaky brain barrier
if i have p450 issues /cyp, my detox cascade functions could be failing in 1st step, then all the cascade, have sense..isnt?
if i have leaky brain barrier, i dont know what to do.
so, all is about methylation, and i only accept methylb12, other thing i tried all, result: sick
5mthf: sick
same: sick (very sick)
adb12: sick
vit c: sick
quercetine: sick
etc etc etc
all my supplement, including my beloved mb12 makes me feel ultra wired, my mb12 started for 1 drop!!!
now i cant handle more than 500mcg per day..and it saved my life, since startted my blood pressure came back to normality
i have to mention that i treated succesfully SIBO and cutted all grains and my gut issues are much much better, swithed to bloating, daily steathorrea etc, to almos normal, but I CANT EAT MORE THATN 10 FOODS.... i have malnutrition, of course.
but working on that.
every time i try other thing: sick
for example, tried coq10 (normal, not ubiquinol) 1/4 of the tablet, and felt sooo weird, tired, sleepy, and lowered my blood pressure until today (took 4 days ago)
i could extend it a lot more, but i will first ask.all the above thing plus this one...
at what point i have my methylation issue?
1 week after an abx course, i think, that was just the trigger, i think i had the issues before but not at the point to feeling sick.
the first i felt was sudden histamine intolerance, without reason, just connected the points, i were feeling so bad after eating.
histamine intoelrance in now my worst isuue, it bothers me more than other thing, i cant handle it more...sincerely, i dont know what more try. any help will be much more that apreciatted, im advanced sufferer so, i know almost all have to be known.
i dont have DAO issues, tested and my DAO activity is perfect, and tried DAO supplements, and nothing...
so i have to think that my issue is due to HNMT (as almost all mi issues depends on methyl transferase etc, its all about methylation, i know)...but.... HNMT depends on SAME as methyl donnor, and ...when tried supplementing same i felt really sick, as much as in the beggining, not histamine, just sick sick (didnt tried histamines to be honest, but it send me back 1000 steps ) so...what i lost here? i dont understand that.
my other issues, when started to be sick were, ultra low blood pressure, POTS, insomnia, big brain fog, big anxiety, difficulty walking...now, i know all them could be due to histamine overload, today, im much better of almost all those, except MAO/COMT relative symptoms.
as well, i have problems with medicines/supplements.... much less than a quarter of recommended doses gives me a big effect..so i think i have 2 options:
1. cyp2d6 /p450 issues
2. leaky brain barrier
if i have p450 issues /cyp, my detox cascade functions could be failing in 1st step, then all the cascade, have sense..isnt?
if i have leaky brain barrier, i dont know what to do.
so, all is about methylation, and i only accept methylb12, other thing i tried all, result: sick
5mthf: sick
same: sick (very sick)
adb12: sick
vit c: sick
quercetine: sick
etc etc etc
all my supplement, including my beloved mb12 makes me feel ultra wired, my mb12 started for 1 drop!!!
now i cant handle more than 500mcg per day..and it saved my life, since startted my blood pressure came back to normality
i have to mention that i treated succesfully SIBO and cutted all grains and my gut issues are much much better, swithed to bloating, daily steathorrea etc, to almos normal, but I CANT EAT MORE THATN 10 FOODS.... i have malnutrition, of course.
but working on that.
every time i try other thing: sick
for example, tried coq10 (normal, not ubiquinol) 1/4 of the tablet, and felt sooo weird, tired, sleepy, and lowered my blood pressure until today (took 4 days ago)
i could extend it a lot more, but i will first ask.all the above thing plus this one...
at what point i have my methylation issue?
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