https://www.sciencedaily.com/releases/2022/04/220429144940.htm
"We discovered that miR-137 helps regulate hypocretin. To experience normal sleep, you need to have the right amount of hypocretin in the brain at the right time, and miR-137 helps with that."
Also interesting, since ME involves immune system dysfunction:
"Most people know that when you are ill you often feel tired. And when you have a fever and the immune system is hard at work, you often suffer from poor sleep. So we know that something happens to the hypocretin level when the body is trying to fight off a virus infection, for example, and we are trying to understand this process," says Birgitte Kornum.
"In the study, we show that one of the immune system's transmitter substances, IL-13, has a special effect on hypocretin. We can tell that when we add IL-13, it affects miR-137 and thus also the level of hypocretin in the body. We still do not know why, though, but we are currently doing tests that may be able to give us an answer."
Another report on sleep studies: https://www.sciencedaily.com/releases/2022/04/220429145059.htm
"We discovered that miR-137 helps regulate hypocretin. To experience normal sleep, you need to have the right amount of hypocretin in the brain at the right time, and miR-137 helps with that."
Also interesting, since ME involves immune system dysfunction:
"Most people know that when you are ill you often feel tired. And when you have a fever and the immune system is hard at work, you often suffer from poor sleep. So we know that something happens to the hypocretin level when the body is trying to fight off a virus infection, for example, and we are trying to understand this process," says Birgitte Kornum.
"In the study, we show that one of the immune system's transmitter substances, IL-13, has a special effect on hypocretin. We can tell that when we add IL-13, it affects miR-137 and thus also the level of hypocretin in the body. We still do not know why, though, but we are currently doing tests that may be able to give us an answer."
Another report on sleep studies: https://www.sciencedaily.com/releases/2022/04/220429145059.htm