BadBadBear
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Has anyone tried myo inositol triphosphate?
Here's what Wikipedia says about
Myo-inositol trispyrophosphate
Here's what Wikipedia says about
Myo-inositol trispyrophosphate
https://en.m.wikipedia.org/wiki/Myo-inositol_trispyrophosphate#cite_note-pmid25070041-2ITPP is a membrane-permeant allosteric regulator of hemoglobin that mildly reduces its oxygen-binding affinity, which shifts the oxygen-hemoglobin dissociation curve to the right and thereby increases oxygen release from the blood into tissue.[1] Phytic acid, in contrast, is not membrane-permeant due to its charge distribution.[1]
Rodent studies in vivo demonstrated increased tissue oxygenation and dose-dependentincreases in endurance during physical exercise, in both healthy mice and transgenic mice expressing a heart failure phenotype.[1]
The substance is believed to have a high potential for use in athletic doping, and liquid chromatography–mass spectrometry tests have been developed to detect ITPP in urine tests.[2] Its use as a performance-enhancing substance in horse racing has also been suspected and similar tests have been developed for horses[3]
ITPP has been studied for potential adjuvant use in the treatment of cancer in conjunction with chemotherapy, due to its effects in reducing tissue hypoxia.[4] Human clinical trials were registered in 2014 under the compound number OXY111A.[5] The substance has also been examined in the context of other illnesses involving hypoxia, such as cardiovascular disease and dementia[2]
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