TheChosenOne
Senior Member
- Messages
- 209
What really works for me is lithium, magnesium, phosphatidylcholine, tyrosine and a B complex.
Magnesium and lithium increase COMT expression. Phosphatidylcholine helps BHMT, but more importantly, it saves some SAMe. SAMe is needed for COMT to work. Phosphatidylcholine is also very beneficial for my sister, so there must be some genetic benefit.
I've run my 23andme file through MTHFRSupport and I was scrolling through it, when I came across an area with a lot of red SNPs in the 'Neurotransmitter Pathway'. I don't think I have a serotonin problem, but I do have a dopamine problem.
The SNPs that you were talking about (++, +- and -- are copied from MTHFRSupport):
MAOB
rs2283729
G
rs1799836
C -
DDC (This is both AAAD and 5HTD in the pathways below, helping create serotonin and dopamine as well.)
rs3735273
CC ++
rs1451375
CC --
rs921451
TT ++
rs2329340
CC
rs1451371
CT +-
DBH
rs77905
AA ++
rs1108580
GG --
rs2007153
CC ++
TPH2
rs4570625
GG
rs17110690
GG
rs4565946
CT
rs10506645
CC
rs1487278
TT
rs11179002
CT
TYR
rs1393350
AG
rs1847134
AC
rs1799989
CC
GCH1
rs4411417
CC ++
rs752688
TT ++
rs8007267
CT +-
PTS
rs3819331
TT
COMT
DBH, GCH1 and COMT might be the biggest problems. I don't have full information about all the SNPs. Maybe you can elaborate it a bit?
PS: I've had OCD/ADD in the past.
Thanks.
Magnesium and lithium increase COMT expression. Phosphatidylcholine helps BHMT, but more importantly, it saves some SAMe. SAMe is needed for COMT to work. Phosphatidylcholine is also very beneficial for my sister, so there must be some genetic benefit.
I've run my 23andme file through MTHFRSupport and I was scrolling through it, when I came across an area with a lot of red SNPs in the 'Neurotransmitter Pathway'. I don't think I have a serotonin problem, but I do have a dopamine problem.
The SNPs that you were talking about (++, +- and -- are copied from MTHFRSupport):
MAOB
rs2283729
G
rs1799836
C -
DDC (This is both AAAD and 5HTD in the pathways below, helping create serotonin and dopamine as well.)
rs3735273
CC ++
rs1451375
CC --
rs921451
TT ++
rs2329340
CC
rs1451371
CT +-
DBH
rs77905
AA ++
rs1108580
GG --
rs2007153
CC ++
TPH2
rs4570625
GG
rs17110690
GG
rs4565946
CT
rs10506645
CC
rs1487278
TT
rs11179002
CT
TYR
rs1393350
AG
rs1847134
AC
rs1799989
CC
GCH1
rs4411417
CC ++
rs752688
TT ++
rs8007267
CT +-
PTS
rs3819331
TT
COMT
DBH, GCH1 and COMT might be the biggest problems. I don't have full information about all the SNPs. Maybe you can elaborate it a bit?
PS: I've had OCD/ADD in the past.
Thanks.
Last edited: