SilverbladeTE
Senior Member
- Messages
- 3,043
- Location
- Somewhere near Glasgow, Scotland
SilverbladeTE - you have a wonderful way with words!! Made me laugh. Spot on ..
*bows with a theatrical flourish*
My pleasure
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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SilverbladeTE - you have a wonderful way with words!! Made me laugh. Spot on ..
Invest in ME's response to the "MRC Funding of Research into ME/CFS" news:
http://www.investinme.org/IIME Statement 2011-01-01.htm
A must-read I think.
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) – Cross-board highlight notice
This highlight notice invites the submission of high-quality proposals in priority areas within CFS/ME research, to all MRC Research Boards.
Immune dysregulation: There is evidence for a disturbance in innate and adaptive immunity in CFS/ME including alterations in cytokine profile, absolute and functional alterations in T cells and NK cells and occurrence of autoantibodies and allergic reactions that may explain some of the manifestations such as fatigue and flu-like symptoms. A number of infectious and environmental exposures have been associated as triggering these changes.
Neuropathology: There is now preliminary evidence supporting the view that inflammatory mechanisms in the brain and spinal cord may underlie the pathophysiology of some severe disease CFS/ME phenotypes. Biobanks are now becoming available and create a unique opportunity for interrogation.
http://www.mrc.ac.uk/Fundingopportunities/Highlightnotices/CFSME/MRC001747
Some interesting extracts from a recent MRC notice (I've underlined some interesting text): [...] So, maybe they did learn some lessons from the PACE Trial?
Quite so! I noticed that too and I think it is remarkable and very important. This is a statement from the MRC that "there is now preliminary evidence supporting the view..." that the name Myalgic Encephalomyelitis is (and always was) medically accurate. And a statement about the evidence for immune dysregulation, which is indeed considerable and has been for a long time but has never before been recognised properly by NICE, the MRC, or physicians in general.Ironically, the latest MRC notice also seems to be implying evidence for the existence of MYALGIC ENCEPHALOMYELITIS: muscle pain and "inflammatory mechanisms in the brain and spinal cord".