Changexpert
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MMAB stands for "methylmalonic aciduria (cobalamin deficiency) cblB type," which is responsible for converting coblamin to AB12. Defects in MMAB SNP's can lead to AB12 deficiency. There is not much evidence on which SNP within MMAB gene upregulate or downregulate AB12 deficiency. However, according to my source (cited below), mutation in this gene can result in AB12 deficiency.
Looking at my test result, I have homozygous conditions for MMAB G16110A (rs7134594) and MMAB/MVK A-818G (rs12314392). According to 23andme result I have, there are 18 SNP's available for MMAB gene. I am homozygous for 11 of them. This could explain why I would get surge of energy from taking AB12, but of course, more research is needed to assess the phenotype and the expressivity of these genes.
Source
http://ghr.nlm.nih.gov/gene/MMAB
Looking at my test result, I have homozygous conditions for MMAB G16110A (rs7134594) and MMAB/MVK A-818G (rs12314392). According to 23andme result I have, there are 18 SNP's available for MMAB gene. I am homozygous for 11 of them. This could explain why I would get surge of energy from taking AB12, but of course, more research is needed to assess the phenotype and the expressivity of these genes.
Source
http://ghr.nlm.nih.gov/gene/MMAB
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