From Dr. Ben Lynch's website:
"Methylfolate is a remarkable nutrient yet it can create significant side effects.
Those who have MTHFR mutations (especially the C677T MTHFR mutation) learn that methylfolate is critical to take. The issue is methylfolate can cause more harm than good if not started at the right time or tapered up slowly in amount.
There appear to be three types of responses to methylfolate:
FIRST: A person who can jump on methylfolate and feel absolutely wonderful. The only down side they experience is why didn’t they know about methylfolate before?!
SECOND: A person starts methylfolate has an amazingly incredible week where they are happy, interacting and alert. Then the second week comes and they switch to wanting to hide in a room by themselves or literally throw dishes across the room out of anger. Or they may become bed ridden from muscle aches, intense headaches or joint pain.
THIRD: A person takes a small amount of methylfolate and feels all the methylfolate side effects right out the gate.
I experienced many of the effects on the list in the third category when I was first (overprescribed) folates and b12 in late 2010, early 2011.
And I can now certainly relate to the 'second' category. Of course I'm not sure that my currrent state can be completely explained by too much methylfolate (or folinic), but I'm very close to being bedridden...can hardly walk without severe pain in my feet...so I'm cutting waaay back, if not stopping the methylfolate for now.
More at the link:
http://mthfr.net/methylfolate-side-effects/2012/03/01/
"Methylfolate is a remarkable nutrient yet it can create significant side effects.
Those who have MTHFR mutations (especially the C677T MTHFR mutation) learn that methylfolate is critical to take. The issue is methylfolate can cause more harm than good if not started at the right time or tapered up slowly in amount.
There appear to be three types of responses to methylfolate:
FIRST: A person who can jump on methylfolate and feel absolutely wonderful. The only down side they experience is why didn’t they know about methylfolate before?!
SECOND: A person starts methylfolate has an amazingly incredible week where they are happy, interacting and alert. Then the second week comes and they switch to wanting to hide in a room by themselves or literally throw dishes across the room out of anger. Or they may become bed ridden from muscle aches, intense headaches or joint pain.
THIRD: A person takes a small amount of methylfolate and feels all the methylfolate side effects right out the gate.
- irritability
- insomnia
- sore muscles
- achy joints
- acne
- rash
- severe anxiety
- palpitations
- nausea
- headaches
- migraines"
I experienced many of the effects on the list in the third category when I was first (overprescribed) folates and b12 in late 2010, early 2011.
And I can now certainly relate to the 'second' category. Of course I'm not sure that my currrent state can be completely explained by too much methylfolate (or folinic), but I'm very close to being bedridden...can hardly walk without severe pain in my feet...so I'm cutting waaay back, if not stopping the methylfolate for now.
More at the link:
http://mthfr.net/methylfolate-side-effects/2012/03/01/