Are there a lot of people who can tell which symptom sets belong to:
paradoxical folate deficiency (need more metafolin, less folates)
low potassium
missing/low co-factor (need something other than metafolin)
insufficient or incorrect form of B12
too much B12
etc.
I added CoQ10 (100mg) and L-Carnatine Fumarate (500mg) last week, and got brain fog. It took me a week to remember to check on what I'd changed, because brain fog is my normal not-methylating symptom. I was busy adjusting metafolin.
I think once somebody is stable, they could lower their metafolin and see if they get these paradoxical... symptoms. But while I'm still figuring out my personal equation, I have no way of knowing for sure what's causing what.
Hi Madie,
Are there a lot of people who can tell which symptom sets belong to:
All of the possibilities you mention are not created equal. One of them, and only one, is potentially quickly dangerous, low potassium.
low potassium - muscle spasms when muscles relaxed, atypical. Itching, headaches, heart arrythmias, nausea, mallaise, paralyzed illium, muscle paralysis, paralyzed breathing, heart failure. It can end up in the ER and NOT BE RECOGNIZED.
Let's look at the other possibilities you mention and what could happen
paradoxical folate deficiency (need more metafolin, less folates) - Partial methylation block remains in place or returns. Healing is restricted to level of active folate available and not blocked. Unpleasant. IBS, cheilitis, peeling fingertips, inflammation, body pain, nausea, depression, joint pain, allergies, asthma, brain fog. May be no different than what has been going on for decades. Temporary neurological damge may increase and become permanent neurological damage.
insufficient b12 - Nothing at all for the most part. Symptoms continue unchanged or very little changed. A sick person continues sick. The only hazard could be where the level of CNS b12 is very low and the person takes a sizable dose of methylfolate, CNS neurological damage might possibly occur especially if maintained over weeks without adding suitable amounts of suitable mb12. Temporary neurological damge may increase and become permanent neurological damage.
incorrect form of B12 - Nothing at all for the most part. Symptoms continue unchanged. A sick person remains sick. The only hazard could be where the level of CNS b12 is very low and the person takes a dose of methylfolate or other folate if effective, CNS neurological damage might possibly occur and become permanent, especially if maintained over weeks without adding suitable amounts of suitable b12. Temporary neurological damge may increase and become permanent neurological damage.
missing/low co-factor (need something other than metafolin) - assuming healing had started, some healing will continue, some will stop in mid stride, possibly frustrating and/or unpleasant but nothing significant is likely to happen
too much MB12 - Hypothetical possibilty of "overdriven methylation". May shift some lab test results. Symptoms unknown if any. I'm not aware of any demonstrations of any actual problems or symptoms. Remains hypothetical. No known danger of any kind. No known toxic effects of any kind with multiple doses up to 35,000,000 mcg each. Can be used at these doses for cyanide clearance.
too much ADB12 - If a lot too much ADb12 is taken over a period of time at CNS penetration levels without corresponding amounts of Mb12 there may be mood changes. Subtle. Quickly correctable with a dose of mb12. This is quite unknown except for 1 instance in trial by two people. I was one of them and had no effect at all. No know danger of any kind. No known toxic effects of any kind at with multiple doses up to 35,000,000 mcg each. Can be used at these doses for cyanide clearance.
too much Hycbl - Might displace active forms from where needed. Mostly nothing at all happens, much healing may cease. No known danger of any kind. No known toxic effects of any kind with multiple doses up to 35,000,000 mcg each. Can be used at these doses for cyanide clearance. May casue acne like lesions. Temporary neurological damge may increase and become permanent neurological damage.
too much Cycbl - Might displace active forms from where needed. Mostly nothing at all happens, much healing may cease. In case of Leber's hereditary optic neuropathy cyanide is deposited around optic nerve killing the optic nerve and causing permanent blindness. Temporary neurological damge may increase and become permanent neurological damage.
The other things are all non-events. Mostly nothing at all happens. A sick person continues sick with a few symptoms changed around. Nothing else at all compares to the effects of low potassium. What the situation actually is can be clarified by what the symptoms are, or are not and the circumstances.