Mary
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More Parkinson's disease research:
https://www.msn.com/en-us/health/ot...S&cvid=a5b5a744217d475288cc3f10cec544c5&ei=98
https://www.cell.com/cell-reports/f...m/retrieve/pii/S2211124724001931?showall=true
https://www.msn.com/en-us/health/ot...S&cvid=a5b5a744217d475288cc3f10cec544c5&ei=98
https://www.cell.com/cell-reports/f...m/retrieve/pii/S2211124724001931?showall=true
Microbial metabolites that can modulate neurodegeneration are promising therapeutic targets. Here, we found that the short-chain fatty acid propionate protects against α-synuclein-induced neuronal death and locomotion defects in a Caenorhabditis elegans model of Parkinson’s disease (PD) through bidirectional regulation between the intestine and neurons. Both depletion of dietary vitamin B12, which induces propionate breakdown, and propionate supplementation suppress neurodegeneration and reverse PD-associated transcriptomic aberrations.