We need good science to identify subgroups, not broad criteria.
The current broad and multiple criteria are only around because of a lack of a biomarker. Subgroups may be explainable by genetics as Dr Davis is looking into.
The studies to be done with Naviaux comparing metabolomics in ME/CFS and depression etc are what we need.
Using weak and broad criteria in a study like this with certain people involved is, to me, a disaster waiting to happen.
Ditch Crawley and White. Reach out to Dr Davis and Dr Naviaux (as foremost experts on metabolomics) for guidance and they have my signature (along with disclosure of study plans as
@A.B. mentioned).
Im all for a study like this. But it needs to be done in the right way, with the right people.
B