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Several studies have found increased Tregs in ME/CFS. Simplified, Tregs help to control the immune response, and autoimmunity. So increased Tregs would point to a weaker immune response in ME/CFS.
However, other evidence point to autoimmunity. The findings of autoantibodies and microglial activation would point to this. Also the fact that rituximabs helps ME/CFS patients (AFAIK, rituximab increases Tregs).
This blog post gives an overview, (thanks @drob31).
So I'm confused. Any thoughts?
However, other evidence point to autoimmunity. The findings of autoantibodies and microglial activation would point to this. Also the fact that rituximabs helps ME/CFS patients (AFAIK, rituximab increases Tregs).
This blog post gives an overview, (thanks @drob31).
So I'm confused. Any thoughts?