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According to research by the NIH, maximal DNA methylation, and axonal regeneration occurred at 80mcg/kg in rats:
http://www.nih.gov/news/health/jun2010/nichd-24.htm
This dose translates to about 1000mcg, for a 80kg human.
The full research article is here:
http://www.jci.org/articles/view/40000
From the article:
"Interestingly, the more folate we gave, the more regrowth we saw, eventually achieving almost a tenfold increase in axonal regeneration," Dr. Iskandar said. Beyond the peak dose of 80 micrograms per kilogram of body weight, the effect decreased but without causing toxicity or nerve damage.
http://www.nih.gov/news/health/jun2010/nichd-24.htm
This dose translates to about 1000mcg, for a 80kg human.
The full research article is here:
http://www.jci.org/articles/view/40000
From the article:
For reasons yet to be elucidated, the beneficial effects of folate supplementation after CNS injury also exhibit a biphasic dose response curve with optimal regeneration occurring at a dose of 80 ?g/kg. A strikingly parallel biphasic response is also observed in both the methylation status of the CNS genome and the protein levels of the Folr as well as in the de novo methyltransferases in response to folate after injury. Specifically, 80 ?g/kg of parenteral FA optimizes Folr1 expression, Dnmt3a and Dnmt3b protein levels, the methylation status of the adult CNS, and its ability to regenerate after injury.
Doses of FA higher than 80 ?g/kg induce relative hypomethylation associated with reduced de novo methyltransferase levels and decreased axonal regeneration. The effect, which reaches levels comparable to those seen in untreated groups only at very high doses, suggests a loss of benefit from higher folate doses rather than toxicity.