Snow Leopard
Hibernating
- Messages
- 5,902
- Location
- South Australia
Not all anti-depressants are the same and some are more effective than others in CFS patients when it comes to depression.
SSRIs have been tested in CFS in double blinded trials and have not only found to be ineffective for CFS symptoms, they have also been found to be ineffective for depression in the same set of patients.
It is also interesting that a number of studies (independently replicated over 3 times) have found elevated, rather than reduced serotonic pathway activity and this was actually hypothesised as being a potential neuro-psychological cause for the fatigue in patients.
MAOIs on the other hand have shown improvements in depression and vitality in CFS patients, with similar rates of side effects to other antidepressants.
SSRIs have been tested in CFS in double blinded trials and have not only found to be ineffective for CFS symptoms, they have also been found to be ineffective for depression in the same set of patients.
It is also interesting that a number of studies (independently replicated over 3 times) have found elevated, rather than reduced serotonic pathway activity and this was actually hypothesised as being a potential neuro-psychological cause for the fatigue in patients.
MAOIs on the other hand have shown improvements in depression and vitality in CFS patients, with similar rates of side effects to other antidepressants.