Freddd
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TRANSLATION OF POPULAR DESCRIPTIVE TERMS TO PRACTICAL CORRECTIONS
During methylation treatments for FMS, CFS, ME, MS. Cures or long term remissions can occur if the clues are understood and followed. Also suggestive of possible ways to detect impending MS, ALS and Parkinsons 10-20 years before diagnosis and hopefully prevent.
There are several popular nutritional treatments and variations for FMS, ME, CFIDS, CFS and several other syndrome names. There is at least one study being conducted for use in MS of exactly the same nutrients because people are having success on them. Many of the same nutritional supplements may be taken in the various programs and by people in general just trying to be healthy.
Under the banner of partial methylation block theory there are a number of programs that center on several forms of cobalamin and of folate with additional vitamins, minerals and supplements. The number and completeness of those other items determine if it is the full methylation protocol or simplified methylation protocol (SMP). Under the banner of Functional Deficiency Diseases which include active b12 deficiencies (4 deficiencies) and induced or paradoxical folate deficiency there is the Active b12 and folate protocol (ABP).
Whatever names these diseases are called they deal with a universe of symptoms that include up to 400 symptoms and signs, depending upon granularity (ie peripheral neuropathy encompasses dozens of possible symptoms and signs). They are in several main categories. They might be grouped as endothelial, epithelial, immune, neurological, blood, and other tissues. Or they might be classified as Skin, GI, lung, heart, veins, arteries, neurological brain, neurological cord, neurological - peripheral, neurological other, neuro-psyc, blood, mood, personality etc.
WHEN TREATED
All of these are flags indicating healing is occurring. Minimizing nervous system response reduces or stops healing, especially of the nervous system. Minimizing ATP response prevents normalization of biochemistry.
1 - Low potassium, almost everybody when healing starts. often called detox
2 - Low folate symptoms even with small doses of Metafolin often called detox
3 - Nervous system activation, everything is perceived as more intense often called detox
4 ATP activation, everything is more energetic and intense often called detox
Whatever distinctions are made, a key characteristic is that symptoms, once well developed, of these syndromes will include multiple tissue types, multiple systems. To the casual observer they appear to be not connected. After all what do blood abnormalities, eczema, irritable bowel syndrome, daily nausea and vomiting, severe fatigue, muscle atrophy, asthma, hypersensitive nervous system responses, muscle pains, MCS, mood and personality changes, widespread body pain, peripheral neuropathy, poly neuropathies, burning bladder, poor immune response, FMS, CFS, autoimmune response, raspy voice, unable to focus eyes, faded vision, multi sensory hallucinations and many others have in common? They all share a common set of nutritional deficiency causes. Some will argue that these are not absolute deficiencies but rather functional deficiencies. For treatment purposes that doesnt matter unless one is trying to restrict access to treatment (insurance wont cover)
The more severely affected a person is the harder hitting the vitamins are when started. There are several initial responses that may occur. In the popular terminology most of them are lumped together under the term DETOX reaction or response. These responses may start in minutes to days depending up many circumstances.
The supplements being considered here are methylcobalamin, adenosylcobalamin, hydroxycobalamin, cyanocobalamin, folic acid, folinic acid, Metafolin-methylfolate, SAM-e, L-carnitine, glutathione, NAC (N-Acetyl Cysteine), Cerefolin-NAC, Whey, Metanx, Deplin.
More rarely Vitamins D A - C, magnesium, zinc
Glutathione, NAC, Cerefolin-NAC, whey are all glutathione or glutathione precursors. The NAC typically overpowers the Cerefolin completely.
Metafolin, methylfolate, Deplin are all methylfolate
Metanx is Metafolin, methylb12 and P5P
B12 forms, in order of effectiveness and likelihood of causing the responses listed here are methylcbl, adenosylcbl, hydroxycbl, cyanocbl
Typically several of these symptoms will appear suddenly with more appearing and worsening over time if corrections are not made. While these groups of symptoms are called frequently called detox depending upon what theories they are operating under most typically they have nothing at all to do with toxins or any actual detox. Typically they are working on a toxin theory of CFS/FMS/ME/MCS etc and that these vitamins and supplements mobilize the toxins which then cause all sorts of symptoms in the groups listed. As the translations are made it is clear that actual detox if it exists, has nothing to do with these symptoms and they can be dangerous to ignore. If it is detox in an actual sense, then it is in what is left after these other things are accounted for and/or corrected and requires much additional definition.
Group 1 Hypokalemia onset. Symptoms may appear with serum potassium as high as approximately 4.3. May become dangerous if ignored. Considered rare with cyanocobalamin it is very common with methylb12 and adensosylb12 and somewhat less so with hydroxycobalamin. This is actually a flag indicating cell formation has started up at a pretty good rate.
IBS Steady constipation , Nausea, Vomiting, Paralyzed Ileum, Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, neck muscles, Muscle weakness, Abnormal heart rhythms (dysrhythmias), Increased pulse rate, Increased blood pressure, Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.
Group 2a - Both
IBS Diarrhea alternating with constipation, IBS Normal alternating with constipation
Group 2b Either or both
Headache, Increased malaise, Fatigue
Group 3 - Induced and/or Paradoxical Folate deficiency or insufficiency
IBS Steady diarrhea, IBS Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract, increased hypersensitive responses , Skin rashes, Increased acne, Skin peeling around fingernails, Skin cracking and peeling at fingertips, Angular Cheilitis, Canker sores, Coated tongue, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptoms, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, Increase irritability, Loss of reflexes, Fevers, Old symptoms returning, Heart palpitations, Bleeding easily,metallic taste, lack of dreaming.
Group 4
Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.
Group 3 symptoms, induced paradoxical folate deficiency or insufficiency are corrected quickly with titrated doses of Metafolin, methylb12 and adenosylb12. If glutathione (precursors) are the cause then larger doses of Metafolin, 7.5-15mg,or maybe more are needed. Different tissues are affected at different levels of methylfolate, it comes or goes in stages. Very strong dose proportionate characteristics are present. Serum folate levels may be high or even very high despite Metafolin responsive deficiency/insufficiency symptoms.
Group 1 symptoms respond readily to potassium. The symptoms and response to potassium may occur at a serum level of approximately 4.3 or less.
IF taking Glutathione, NAC, Cerefolin-NAC, whey, all glutathione or glutathione precursors
AND often sudden onset of several group 3 symptoms (Detox) maybe in a sequence, ie pain and inflammation the first day, cheilitis occurs on day 2-3 and IBS on day 5-6, plus any group 2 symptoms. Symptoms increase in both quantity and intensity for weeks or months and can vary from mild to extreme. They do not go away when glutathione/NAC are stopped and may continue for up to at least 6 months despite daily doses of Metafoil, mb12 and adb12.
THEN Induced Paradoxical Folate Deficiency onset. B12 deficiencies follow in a week for methylb12 deficiency symptoms and several weeks for adenosylb12 deficiency symptoms. None of the other supplements can overcome the effects of glutathione or NAC.
ELSE - all other conditions
IF injecting b12
AND itchy bumps and acne type lesions appear mostly on scalp and face but not exclusive
THEN B12 was hydroxycbl OR photolytically deteriorated methylcbl OR cyanocbl, Lesions can be reversed in days with methylcbl injections not exposed to light at all.
IF starting or adding methylb12, adenposylb12 or hydroxycbl, AND OR Metafolin (perhaps 80%)
AND the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
THEN this can be the onset of Hypokalemia triggered by sudden widespread healing onset. This usually occurs as soon as methylation therapy starts widespread healing process by allowing DNA replications with methylb12 and methylfolate.
IF adding adenosylcobalamin AND OR L-carnitine fumarate AND OR SAM-e to program (perhaps 50%)
AND the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
THEN this can be the onset of Hypokalemia triggered by sudden healing and /or muscle growth. This usually occurs when the person has experienced muscle shrinkage perhaps from decades of inactivity, as soon as these supplements step up mitochondria functioning.
IF adding or increasing any of Vitamins D, A, E, or C, magnesium, zinc (perhaps 10%)
AND on the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is the primary form found in vegetable source. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF starting or increasing folic acid
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folic acid is the most oxidized form of folate that anybody can use. In some unknown percentage of people who appear unable to convert folic acid adequately to methylfolate the accumulating unconverted folic acid can actually block the methylfolate.
IF starting or increasing folinic acid
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is a less oxidized form of folate than folic acid.. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF an increase in dietary vegetable folate, green drinks, a garden feast
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is the primary form found in vegetable source. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF starting or increasing folic acid AND OR starting or increasing folinic acid AND OR an increase in dietary vegetable folate
AND the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Insufficiency AND this can be the onset of Hypokalemia triggered by sudden healing
IF starting or Methylfolate Metafolin starting low and titrating
AND the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
AND OR usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Insufficiency, a donut hole deficiency. The effects of folate deficiency/insufficiency comes in layers. Several tissue groups can be healing at the same time as other tissue groups are deteriorating. IBS and angular cheilitis can be worsening at the same time as muscles are healing or growing. There is a dose of Metafolin that can start more tissue formation than the same dose can sustain causing a Paradoxical Folate Insufficiency at the same time. In some people at least as they increase Metafolin the need for potassium increases approximately proportionately. The donut hole can be closed with total daily doses of Metafolin of about 15mg for many people.
During methylation treatments for FMS, CFS, ME, MS. Cures or long term remissions can occur if the clues are understood and followed. Also suggestive of possible ways to detect impending MS, ALS and Parkinsons 10-20 years before diagnosis and hopefully prevent.
There are several popular nutritional treatments and variations for FMS, ME, CFIDS, CFS and several other syndrome names. There is at least one study being conducted for use in MS of exactly the same nutrients because people are having success on them. Many of the same nutritional supplements may be taken in the various programs and by people in general just trying to be healthy.
Under the banner of partial methylation block theory there are a number of programs that center on several forms of cobalamin and of folate with additional vitamins, minerals and supplements. The number and completeness of those other items determine if it is the full methylation protocol or simplified methylation protocol (SMP). Under the banner of Functional Deficiency Diseases which include active b12 deficiencies (4 deficiencies) and induced or paradoxical folate deficiency there is the Active b12 and folate protocol (ABP).
Whatever names these diseases are called they deal with a universe of symptoms that include up to 400 symptoms and signs, depending upon granularity (ie peripheral neuropathy encompasses dozens of possible symptoms and signs). They are in several main categories. They might be grouped as endothelial, epithelial, immune, neurological, blood, and other tissues. Or they might be classified as Skin, GI, lung, heart, veins, arteries, neurological brain, neurological cord, neurological - peripheral, neurological other, neuro-psyc, blood, mood, personality etc.
WHEN TREATED
All of these are flags indicating healing is occurring. Minimizing nervous system response reduces or stops healing, especially of the nervous system. Minimizing ATP response prevents normalization of biochemistry.
1 - Low potassium, almost everybody when healing starts. often called detox
2 - Low folate symptoms even with small doses of Metafolin often called detox
3 - Nervous system activation, everything is perceived as more intense often called detox
4 ATP activation, everything is more energetic and intense often called detox
Whatever distinctions are made, a key characteristic is that symptoms, once well developed, of these syndromes will include multiple tissue types, multiple systems. To the casual observer they appear to be not connected. After all what do blood abnormalities, eczema, irritable bowel syndrome, daily nausea and vomiting, severe fatigue, muscle atrophy, asthma, hypersensitive nervous system responses, muscle pains, MCS, mood and personality changes, widespread body pain, peripheral neuropathy, poly neuropathies, burning bladder, poor immune response, FMS, CFS, autoimmune response, raspy voice, unable to focus eyes, faded vision, multi sensory hallucinations and many others have in common? They all share a common set of nutritional deficiency causes. Some will argue that these are not absolute deficiencies but rather functional deficiencies. For treatment purposes that doesnt matter unless one is trying to restrict access to treatment (insurance wont cover)
The more severely affected a person is the harder hitting the vitamins are when started. There are several initial responses that may occur. In the popular terminology most of them are lumped together under the term DETOX reaction or response. These responses may start in minutes to days depending up many circumstances.
The supplements being considered here are methylcobalamin, adenosylcobalamin, hydroxycobalamin, cyanocobalamin, folic acid, folinic acid, Metafolin-methylfolate, SAM-e, L-carnitine, glutathione, NAC (N-Acetyl Cysteine), Cerefolin-NAC, Whey, Metanx, Deplin.
More rarely Vitamins D A - C, magnesium, zinc
Glutathione, NAC, Cerefolin-NAC, whey are all glutathione or glutathione precursors. The NAC typically overpowers the Cerefolin completely.
Metafolin, methylfolate, Deplin are all methylfolate
Metanx is Metafolin, methylb12 and P5P
B12 forms, in order of effectiveness and likelihood of causing the responses listed here are methylcbl, adenosylcbl, hydroxycbl, cyanocbl
Typically several of these symptoms will appear suddenly with more appearing and worsening over time if corrections are not made. While these groups of symptoms are called frequently called detox depending upon what theories they are operating under most typically they have nothing at all to do with toxins or any actual detox. Typically they are working on a toxin theory of CFS/FMS/ME/MCS etc and that these vitamins and supplements mobilize the toxins which then cause all sorts of symptoms in the groups listed. As the translations are made it is clear that actual detox if it exists, has nothing to do with these symptoms and they can be dangerous to ignore. If it is detox in an actual sense, then it is in what is left after these other things are accounted for and/or corrected and requires much additional definition.
Group 1 Hypokalemia onset. Symptoms may appear with serum potassium as high as approximately 4.3. May become dangerous if ignored. Considered rare with cyanocobalamin it is very common with methylb12 and adensosylb12 and somewhat less so with hydroxycobalamin. This is actually a flag indicating cell formation has started up at a pretty good rate.
IBS Steady constipation , Nausea, Vomiting, Paralyzed Ileum, Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, neck muscles, Muscle weakness, Abnormal heart rhythms (dysrhythmias), Increased pulse rate, Increased blood pressure, Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.
Group 2a - Both
IBS Diarrhea alternating with constipation, IBS Normal alternating with constipation
Group 2b Either or both
Headache, Increased malaise, Fatigue
Group 3 - Induced and/or Paradoxical Folate deficiency or insufficiency
IBS Steady diarrhea, IBS Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract, increased hypersensitive responses , Skin rashes, Increased acne, Skin peeling around fingernails, Skin cracking and peeling at fingertips, Angular Cheilitis, Canker sores, Coated tongue, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptoms, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, Increase irritability, Loss of reflexes, Fevers, Old symptoms returning, Heart palpitations, Bleeding easily,metallic taste, lack of dreaming.
Group 4
Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.
Group 3 symptoms, induced paradoxical folate deficiency or insufficiency are corrected quickly with titrated doses of Metafolin, methylb12 and adenosylb12. If glutathione (precursors) are the cause then larger doses of Metafolin, 7.5-15mg,or maybe more are needed. Different tissues are affected at different levels of methylfolate, it comes or goes in stages. Very strong dose proportionate characteristics are present. Serum folate levels may be high or even very high despite Metafolin responsive deficiency/insufficiency symptoms.
Group 1 symptoms respond readily to potassium. The symptoms and response to potassium may occur at a serum level of approximately 4.3 or less.
IF taking Glutathione, NAC, Cerefolin-NAC, whey, all glutathione or glutathione precursors
AND often sudden onset of several group 3 symptoms (Detox) maybe in a sequence, ie pain and inflammation the first day, cheilitis occurs on day 2-3 and IBS on day 5-6, plus any group 2 symptoms. Symptoms increase in both quantity and intensity for weeks or months and can vary from mild to extreme. They do not go away when glutathione/NAC are stopped and may continue for up to at least 6 months despite daily doses of Metafoil, mb12 and adb12.
THEN Induced Paradoxical Folate Deficiency onset. B12 deficiencies follow in a week for methylb12 deficiency symptoms and several weeks for adenosylb12 deficiency symptoms. None of the other supplements can overcome the effects of glutathione or NAC.
ELSE - all other conditions
IF injecting b12
AND itchy bumps and acne type lesions appear mostly on scalp and face but not exclusive
THEN B12 was hydroxycbl OR photolytically deteriorated methylcbl OR cyanocbl, Lesions can be reversed in days with methylcbl injections not exposed to light at all.
IF starting or adding methylb12, adenposylb12 or hydroxycbl, AND OR Metafolin (perhaps 80%)
AND the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
THEN this can be the onset of Hypokalemia triggered by sudden widespread healing onset. This usually occurs as soon as methylation therapy starts widespread healing process by allowing DNA replications with methylb12 and methylfolate.
IF adding adenosylcobalamin AND OR L-carnitine fumarate AND OR SAM-e to program (perhaps 50%)
AND the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
THEN this can be the onset of Hypokalemia triggered by sudden healing and /or muscle growth. This usually occurs when the person has experienced muscle shrinkage perhaps from decades of inactivity, as soon as these supplements step up mitochondria functioning.
IF adding or increasing any of Vitamins D, A, E, or C, magnesium, zinc (perhaps 10%)
AND on the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is the primary form found in vegetable source. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF starting or increasing folic acid
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folic acid is the most oxidized form of folate that anybody can use. In some unknown percentage of people who appear unable to convert folic acid adequately to methylfolate the accumulating unconverted folic acid can actually block the methylfolate.
IF starting or increasing folinic acid
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is a less oxidized form of folate than folic acid.. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF an increase in dietary vegetable folate, green drinks, a garden feast
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Deficiency (or Insufficiency). Folinic acid is the primary form found in vegetable source. In some unknown percentage of people who appear unable to convert folinic acid adequately to methylfolate the accumulating unconverted folinic acid can actually block the methylfolate.
IF starting or increasing folic acid AND OR starting or increasing folinic acid AND OR an increase in dietary vegetable folate
AND the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
AND usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Insufficiency AND this can be the onset of Hypokalemia triggered by sudden healing
IF starting or Methylfolate Metafolin starting low and titrating
AND the approximately 3rd day or later onset of symptoms (Detox) from Group 1 and/or group2
AND OR usually takes a number of days to accumulate to a level leading to onset of symptoms (Detox) from Group 3 and/or group2
THEN this can be the onset of Paradoxical Folate Insufficiency, a donut hole deficiency. The effects of folate deficiency/insufficiency comes in layers. Several tissue groups can be healing at the same time as other tissue groups are deteriorating. IBS and angular cheilitis can be worsening at the same time as muscles are healing or growing. There is a dose of Metafolin that can start more tissue formation than the same dose can sustain causing a Paradoxical Folate Insufficiency at the same time. In some people at least as they increase Metafolin the need for potassium increases approximately proportionately. The donut hole can be closed with total daily doses of Metafolin of about 15mg for many people.